MAPK12 Mitogen-Activated Protein Kinase 12 Human Recombinant Protein

SKU PROTP53778
Size 5ug, 20ug, 1mg
Applications Cell Culture

Overview

Product Name MAPK12 Mitogen-Activated Protein Kinase 12 Human Recombinant Protein
SKU/Catalog Number PROTP53778
Size 5ug, 20ug, 1mg
Storage & Handling Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.
Description MAPK12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 387 amino acids (1-367 a.a.) and having a molecular mass of 44.1kDa.
MAPK12 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Cite This Product MAPK12 Mitogen-Activated Protein Kinase 12 Human Recombinant Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTP53778)
Applications Cell Culture

Target Info

Protein Target Info (Source: Uniprot.org)

Uniprot Id P53778
Gene Name MAPK12
Protein Name Mitogen-activated protein kinase 12
Tissue Specificity Highly expressed in skeletal muscle and heart.
Alternative Names Mitogen-activated protein kinase 12;MAP kinase 12;MAPK 12;2.7.11.24
Subcellular Localization Cytoplasm. Nucleus. Mitochondrion. Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity).

Ontology

Protein Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma- radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

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PROTP53778
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Customer Q&As

  • Q: Is this protein biologically active?
    A: If there is no biological activity section mentioned in our data sheet it means that we have not assessed the bio-functionality of the protein to date. So, we cannot guarantee that the protein is biologically active.
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