MTDH Metadherin Human Recombinant Protein

Size 2ug, 10ug, 1mg
Applications Cell Culture


Product Name MTDH Metadherin Human Recombinant Protein
SKU/Catalog Number PROTQ86UE4
Size 2ug, 10ug, 1mg
Storage & Handling Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.
Description Metadherin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Val271-Asn456) containing 196 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 21.5kDa.
Cite This Product MTDH Metadherin Human Recombinant Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTQ86UE4)
Applications Cell Culture

Target Info

Protein Target Info (Source:

Uniprot Id Q86UE4
Gene Name MTDH
Protein Name Protein LYRIC
Tissue Specificity Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Alternative Names Protein LYRIC;3D3/LYRIC;Astrocyte elevated gene-1 protein;AEG-1;Lysine-rich CEACAM1 co-isolated protein;Metadherin;Metastasis adhesion protein;MTDH;AEG1, LYRIC;
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane


Protein Function Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

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Customer Q&As

  • Q: Is this protein biologically active?
    A: If there is no biological activity section mentioned in our data sheet it means that we have not assessed the bio-functionality of the protein to date. So, we cannot guarantee that the protein is biologically active.
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