Research Spotlight - November 2018

At Boster, our customers’ research is our priority. Our mission is to help customers achieve their research goals so that they can stay on the cutting edge of research.

This November, we’d like to feature a selected number of recently published research from the scientists whom Boster has served. Scroll down to see 10 research discoveries from different fields.

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Engineered nanoparticles disguised as macrophages for trapping lipopolysaccharide and preventing endotoxemia
Authors: Shen, S., Han, F., Yuan, A., Wu, L., Cao, J., Qian, J., Qi, X., Yan, Y...
Journal: Biomaterials
Endotoxemia is a severe pathophysiology induced by bacterial endotoxin (also known as lipopolysaccharide, LPS), causing high mortality in clinic due to the life-threatening syndromes, such as sepsis, shock, and multiple organ dysfunction…

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Preparation of self‐regulating/anti‐adhesive hydrogels and their ability to promote healing in burn wounds
Authors: Liang, M., Chen, Z., Wang, F., Liu, L., Wei, R., & Zhang, M.
Journal: Journal of Biomedical Materials Research Part B: Applied Biomaterials
Few burn dressings can self‐regulate the optimal humidity levels that are required for wound healing, while also providing good anti‐adhesive properties to prevent damage that can occur when wound dressings are changed…

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CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression
Authors: Q., Yi, D.Y., Xue, B.Z., Wen, W.W., Lu, Y.P., Abdelmaksou, A...
Journal: Cell Death & Disease
Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90+…

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Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients
Authors: Duan, B., Bai, J., Qiu, J., Wang, J., Tong, C., Wang, X., Miao, J...
Journal: EBioMedicine
Background: There is an urgent need for the identification of new, clinically useful biomarkers of CRC to enhance diagnostic and prognostic capabilities. Methods: We performed proteomic profiling on serum samples from paired pre-...

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Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial‐mesenchymal transition and cancer stem cell‐like properties by modulating FOXM1
Authors: Cao, J., Li, J., Sun, L., Qin, T., Xiao, Y., Chen, K., Qian, W., Duan, W...
Journal: Molecular Oncology
Pancreatic stellate cells (PSCs), a key component of the tumor microenvironment, contribute to tumor invasion, metastasis, and chemoresistance. Osteopontin (OPN), a phosphorylated glycoprotein, is overexpressed in pancreatic...

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FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway
Authors: Huang, T., Liu, D., Wang, Y., Li, P., Sun, L., Xiong, H., Dai, Y...
Journal: Cellular Physiology and Biochemistry
Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest that the bioavailability of the potent pro-tumor function…

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Liver X receptor activation reduces gastric cancer cell proliferation by suppressing Wnt signalling via LXRβ relocalization
Authors: Wang, Q., Feng, F., Wang, J., Ren, M., Shi, Z., Mao, X., Zhang, H...
Journal: Journal of Cellular and Molecular Medicine
Liver X receptors (LXRs) are involved in various diseases associated with lipid disorders, and in regulating cancer cell proliferation. However, the underlying molecular mechanisms, especially those in gastric cancer (GC) remain to be clarified...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105)
MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells
Authors: Chandimali, N., Huynh, D.L., Zhang, J.J., Lee, J.C., Yu, D.Y...
Journal: Cancer Gene Therapy
Previously, we demonstrated that Prx II is important for survival of the gefitinib-resistant A549 (A549/GR) cell line, an NSCLC cell line derived by repeated exposure to gefitinib. Therefore, in this study, we used A549/GR cells to investigate…

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Cited Boster Product(s): Anti-PROM1 Antibody (PA2049)
Mechanical stress protects against osteoarthritis via regulation of the AMPK/NF‐κB signaling pathway
Authors: Yang, Y., Wang, Y., Kong, Y., Zhang, X., Zhang, H., Gang, Y...
Journal: Journal of Cellular Physiology
Mechanical stress plays a key role in regulating cartilage degradation in osteoarthritis (OA). The aim of this study was to evaluate the effects and mechanisms of mechanical stress on articular cartilage. A total of 80 male Sprague‐Dawley…

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IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma
Authors: Wang, L., Bi, X.W., Zhu, Y.J., He, Y.Z., Lai, Q.Y., Xia, Z.J...
Journal: Cancer Communications
Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma often resistant to chemotherapy. Serum level of soluble IL-2 receptor α (IL-2Rα) is elevated in NKTCL patients and correlates...

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