Recombinant Human BMP-6 Protein

TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

Product Info Summary

SKU: PROTP22004-2
Size: Various Sizes
Origin Species: Mouse
Source: HEK293 cells
Application: Cell Culture

Product Name

Recombinant Human BMP-6 Protein

See all BMP-6 products

SKU/Catalog Number

PROTP22004-2

Size

Various Sizes

Form

Solid; white powder or thin/invisible film

Description

TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Recombinant Human BMP-6 Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTP22004-2)

Formulation

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

Predicted MW

57.226kDa

Biological Activity And Protein Authenticity

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.

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Validation Images & Assay Conditions

Gene/Protein Information For BMP6 (Source: Uniprot.Org, NCBI)

Uniprot ID

P22004

Gene ID

654

Gene Name

BMP6

Full Name

Bone morphogenetic protein 6

Weight

57.226kDa

Superfamily

TGF-beta family

Alternative Names

BMP6; BMP-6; bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR; VGR1; Vgr-1 BMP6 VGR, VGR1 bone morphogenetic protein 6 bone morphogenetic protein 6|VG-1-R|VG-1-related protein|vegetal related growth factor (TGFB-related)

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on BMP6, check out the BMP6 Infographic

BMP6 infographic

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In this infographic you will see the following information for BMP6: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

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