Recombinant Human MANF Protein

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

Product Info Summary

SKU: PROTP55145-2
Size: Various Sizes
Origin Species: Mouse
Source: E. Coli
Application: Cell Culture

Product Name

Recombinant Human MANF Protein

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SKU/Catalog Number

PROTP55145-2

Size

Various Sizes

Form

Solid; white powder or thin/invisible film

Description

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Recombinant Human MANF Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTP55145-2)

Formulation

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

Predicted MW

20.7kDa

Biological Activity And Protein Authenticity

Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.

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Validation Images & Assay Conditions

Gene/Protein Information For MANF (Source: Uniprot.Org, NCBI)

Uniprot ID

P55145

Gene ID

7873

Gene Name

MANF

Full Name

Mesencephalic astrocyte-derived neurotrophic factor

Weight

20.7kDa

Superfamily

ARMET family

Alternative Names

Arginine-Rich Protein; arginine-rich, mutated in early stage tumors; ARMET; ARP; MANF; mesencephalic astrocyte-derived neurotrophic factor; Protein ARMET MANF ARMET, ARP mesencephalic astrocyte derived neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor|arginine-rich, mutated in early stage tumors

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on MANF, check out the MANF Infographic

MANF infographic

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In this infographic you will see the following information for MANF: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

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Size

Total: $230

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