Recombinant Human sDLL-4 Protein

Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.0 kDa glycoprotein containing 498 amino-acid residues.

Product Info Summary

SKU: PROTQ9NR61
Size: Various Sizes
Origin Species: Mouse
Source: HEK293 cells
Application: Cell Culture

Product Name

Recombinant Human sDLL-4 Protein

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SKU/Catalog Number

PROTQ9NR61

Size

Various Sizes

Form

Solid; white powder or thin/invisible film

Description

Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.0 kDa glycoprotein containing 498 amino-acid residues.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Recombinant Human sDLL-4 Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTQ9NR61)

Formulation

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

Predicted MW

74.605kDa

Biological Activity And Protein Authenticity

The sDLL-4, when immobilized at concentrations >1.5 μg/mL will inhibit myogenesis in C2C12 cells.

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Validation Images & Assay Conditions

Gene/Protein Information For DLL4 (Source: Uniprot.Org, NCBI)

Uniprot ID

Q9NR61

Gene ID

54567

Gene Name

DLL4

Full Name

Delta-like protein 4

Weight

74.605kDa

Alternative Names

Delta 4 precursor; delta 4; delta ligand 4; delta4; delta-like 4 (Drosophila); delta-like 4 homolog (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4 DLL4 AOS6, delta4, hdelta2 delta like canonical Notch ligand 4 delta-like protein 4|delta 4|delta ligand 4|delta-like 4 homolog|delta-like 4 protein|drosophila Delta homolog 4|notch ligand DLL4|notch ligand delta-2

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

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PROTQ9NR61
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