Recombinant Murine APRIL Protein

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.

Product Info Summary

SKU: PROTQ9D777-1
Size: Various Sizes
Origin Species: Mouse
Source: E. Coli
Application: Cell Culture

Product Name

Recombinant Murine APRIL Protein

See all APRIL/TNFSF13 products

SKU/Catalog Number

PROTQ9D777-1

Size

Various Sizes

Form

Solid; white powder or thin/invisible film

Description

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Recombinant Murine APRIL Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTQ9D777-1)

Formulation

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

Predicted MW

26.889kDa

Biological Activity And Protein Authenticity

Measured by its ability to induce cell proliferation of activated T cells.

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Validation Images & Assay Conditions

Gene/Protein Information For Tnfsf13 (Source: Uniprot.Org, NCBI)

Uniprot ID

Q9D777

Gene ID

69583

Gene Name

Tnfsf13

Full Name

Tumor necrosis factor ligand superfamily member 13

Weight

26.889kDa

Superfamily

tumor necrosis factor family

Alternative Names

A proliferation-inducing ligand; APRIL; APRILFLJ57090; CD256 antigen; CD256; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNFSF13; TRDL1; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; ZTNF2 Tnfsf13|2310026N09Rik, April, TA, TRD, Tall2, Tnlg7b, Trdl1|tumor necrosis factor (ligand) superfamily, member 13|tumor necrosis factor ligand superfamily member 13|a proliferation-inducing ligand|tumor necrosis factor ligand 7b

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Tnfsf13, check out the Tnfsf13 Infographic

Tnfsf13 infographic

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