Recombinant Murine IL-13 Protein

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.

Product Info Summary

SKU: PROTP20109-1
Size: Various Sizes
Origin Species: Mouse
Source: E. Coli
Application: Cell Culture

Product Name

Recombinant Murine IL-13 Protein

See all IL-13 products

SKU/Catalog Number

PROTP20109-1

Size

Various Sizes

Form

Solid; white powder or thin/invisible film

Description

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Recombinant Murine IL-13 Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTP20109-1)

Formulation

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

Predicted MW

14.108kDa

Biological Activity And Protein Authenticity

The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 105 units/mg.

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Validation Images & Assay Conditions

Gene/Protein Information For Il13 (Source: Uniprot.Org, NCBI)

Uniprot ID

P20109

Gene ID

16163

Gene Name

Il13

Full Name

Interleukin-13

Weight

14.108kDa

Superfamily

IL-4/IL-13 family

Alternative Names

ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600 Il13|Il-, Il-13|interleukin 13|interleukin-13|T-cell activation protein P600

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

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PROTP20109-1
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