COQ2 Antibodies

AND COQ2 ELISA kits, COQ2 Proteins

Many biological assays use antibodies to detect COQ2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COQ2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COQ2 antibodies...

We validate the specificity of these antibodies to COQ2 by testing them on tissues known to express COQ2 positively and negatively. Browse below to find the COQ2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COQ2 Infographic by Boster Bio

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COQ2 Overview

Facts about 4-hydroxybenzoate polyprenyltransferase, mitochondrial.

COQ2 3D structure. Source: alphafold

4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2)

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the last reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the warmth of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.

Gene Information

Human
Gene Name:	COQ2
Uniprot:	Q96H96
Entrez:	27235

Family

Belongs to:

UbiA prenyltransferase family

Alternative Names

4-hydroxybenzoate polyprenyltransferase; coenzyme Q2 homolog, prenyltransferase (yeast); COQ2 homolog; EC 2.5.1; EC 2.5.1.39; FLJ13014; hCOQ2; mitochondrial; Para-hydroxybenzoate--polyprenyltransferase; para-hydroxybenzoate-polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase

Molecular Weight

Mass (kDA):
40.489 kDA

Genomic Context


Human

Location:	4q21.22-q21.23
Sequence:	4; NC_000004.12 (83263824..83285134, complement)

Tissue Specificity

Widely expressed. Present in all of the tissues tested. Expressed at higher level in skeletal muscle, adrenal glands and the heart.

Subcellular Localizations

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.

Diseases

Myopathy
Ataxia
Mitochondrial Diseases
Mitochondrial Encephalomyopathies
Cerebellar Ataxia
Kidney Diseases
Nephrotic Syndrome
Myalgia
Atrophy
Steroid-resistant Nephrotic Syndrome
Myositis

Kidney Failure, Chronic
Leigh Disease
Encephalopathies
Dyslipidemias
Neuromuscular Diseases
Oliguria

Pathways

Transport
Cell Death
Prenylation
Oxidative Phosphorylation
Localization
Electron Transport
Pathogenesis

Translation
Riboflavin Transport

PTMs

Phosphorylation

Oxidation

Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COQ2

References

PMID: 15153069 by Forsgren M., et al. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ2.

PMID: 17374725 by Lopez-Martin J.M., et al. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis.