Boster Bio Life Science Blog

  1. Research Spotlight - June 2022

    The June issue of Research Spotlight highlights research advancements from scientists whom we have served.

    Read about new studies outlining potential treatments to promote tissue repair and regeneration. For example, one study demonstrated the significance of EE for cardiac repair.

    Scientists also investigated the promising roles of ROS-scavenging hydrogel, responsive Mn3O4 nanoplatform, and a novel 3D-printed porous bioactive ceramic scaffold for spinal cord injury, gastric cancer, and bone injury, respectively.

    Other papers uncovered the molecular mechanisms of SIRT1, Neat1, cathepsin B/NLRP3, and FASN in different diseases and cancer.

    Scroll down to learn more about these 10 research discoveries.

    Environmental Eustress Improves Postinfarction Cardiac Repair via Enhancing Cardiac Macrophage Survival

    Authors: Bai, P.Y., Chen, S.Q., Jia, D.L., Pan, L.H., Liu, C.B., Luo, J.L., Yang, Y…
    Journal: Science Advances

    Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown...

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    Cited Boster Product(s): Mouse BDNF ELISA Kit PicoKine® (EK0309)

    Journal Cover

    Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy

    Authors: Jiang, R.H., Dong, C.J., Chen, Z.L., Cheng, S., Yang, J.X., Gao, W.Y.
    Journal: Oxidative Medicine and Cellular Longevity

    Random-pattern skin flap necrosis limits its application in the clinic. It is still a challenge for plastic surgeons. Catalpol is an effective ingredient extracted from Rehmannia glutinosa, which is reported to promote angiogenesis and protect against ischemic cerebral disease. The aim of our experiment is to assess whether catalpol...

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    Cited Boster Product(s): Anti-VE-Cadherin-5 Cdh5-Antibody Picoband™ (A02632-2)

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    Research Spotlight - June 2022
  2. Research Spotlight - May 2022

    For this month’s Research Spotlight, we highlight 10 new research publications from scientists whom Boster has served.

    In the field of cancer immunotherapy, data from two studies point toward the anti-lymphoma and anti-bladder cancer effects exerted by ADAM10 and iDAMP inhibitors respectively. Additionally, scientists present the promising potential of CEACAM 5, PCL22-186, and lncSLCO1C1 as new biomarkers for predicting cancer cells’ radiosensitivity, cancer progression, and resistance...

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    Research Spotlight - May 2022
  3. 6 IHC Controls You Should Know

    Immunohistochemistry (IHC) is a popular protein detection method that utilizes antibody-antigen interactions to visualize the distribution and localization of specific cellular components within cells and in their proper tissue context.

    In the lab, researchers invest time and effort to optimize the sample preparation and sample staining processes of IHC. When successful, the results produce a strong and specific signal.

    However, how do we know the results have been interpreted...

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    6 IHC Controls You Should Know
  4. Research Spotlight - April 2022

    Every month, we feature 10 research studies from scientists whom we have served. In our April edition of Research Spotlight, scientists focus on finding novel delivery systems to improve the poor delivery efficiency of therapeutic biomolecules.

    One research paper provided new insights into how renal exosomes are aroused by β-catenin, underscoring an important therapeutic strategy for CKD. Studies highlighting the promising potential of engineered EGCG-containing nanoassemblies, microalgae-based...

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    Research Spotlight - April 2022
  5. Research Spotlight – March 2022

    The March edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

    In this edition, scientists discussed how a better understanding of the PD-L1 expression regulation can be pivotal in achieving better clinical outcomes in EBV-infected cancer patients. Another research study proposed a self-powered smart patch that serves as a reservoir of chemokine-/neural-directing exosomes, offering a serviceable strategy to stimulate skin neuro-engineering and regeneration of tissues and organs.

    In terms of bone diseases, one paper revealed the potential role of Calca, an osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH. Several development strategies in the fields of nanotechnology and biomaterials were also achieved through the construction of cell-responsive peptide assemblies and nanorod-like coating with ions doping.

    Explore below for a closer look at these research discoveries!

    EBV miRNAs BART11 and BART17-3p Promote Immune Escape Through the Enhancer-Mediated Transcription of PD-L1

    Authors: Wang, J., Ge, J., Wang, Y., Xiong, F., Guo, J., Jiang, X., Zhang, L…
    Journal: Nature Communications

    Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and several lymphomas. PD-L1 expression is elevated in EBV-positive NPC and GC tissues; however, the specific mechanisms underlying the EBV-...

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    Cited Boster Product(s): Mouse IL-2 ELISA Kit PicoKine® (EK0398); Mouse Granzyme B ELISA Kit PicoKine® (EK1115); Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine® (EK0375)

    Journal Cover

    MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

    Authors: Feng, L., Li, C., Zeng, L.W., Gao, D., Sun, Y.H., Zhong, L., Lin, H…
    Journal: Signal Transduction and Targeted Therapy

    Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered physiological and pathological effects are regulated at the receptor level is unclear. Here, we...

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    Research Spotlight – March 2022
  6. 5 Tips To Reduce Autofluorescence

    The common problem for all fluorescence-based cell detection methods is the cells’ natural fluorescence. Cellular autofluorescence is due to the presence of various biological structures, such as collagen, elastin, NADPH, flavins, mitochondria, and lysosomes, which usually absorb in UV to blue range (355-488 nm) and emit in the blue to green range (350-550 nm). Therefore, autofluorescence interferes with analysis by reducing signal sensitivity and resolution of fluorochromes that operate in that range – FITC, GFP, and Pacific Blue to name a few.

    To subtract this background and prevent false positives, it is crucial to include unstained controls and set proper PMTs and gating. However, it is even more important to minimize autofluorescence as much as possible. Below are some handy tips to follow.

    Use a lower concentration of FCS in the staining buffer

    Fetal calf serum (FCS) absorbs at the violet and blue spectra. Therefore, serum present in FACS buffer as well as the culture medium can increase autofluorescence. It is critical to standardize the optimum concentration of FCS in the staining buffer to strike a compromise between blocking non-specific antibody binding and minimizing autofluorescence. Most labs use FCS at 1% to 10%. From our experience, lower concentrations of FCS work as well as 10%. If low FCS concentration does not remove autofluorescence, we suggest switching to bovine serum albumin (BSA)...

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    5 Tips To Reduce Autofluorescence
  7. Research Spotlight – February 2022

    In this month’s Research Spotlight, we highlight a range of our customers’ publications that investigate complex challenges and the development of life-changing innovations to improve patient health.

    February 2022

    In this month’s Research Spotlight, we highlight a range of our customers’ publications that investigate complex challenges and the development of life-changing innovations to improve patient health.

    Find out how tNIR light treatment might serve as a noninvasive therapeutic alternative for regulating neuronal functions via the improvement of mitochondrial dysfunction mediated by the SIRT1/PGC-1α pathway. In addition, as more studies reveal the key role of circRNAs in cancer, researchers dive deeper into the molecular mechanism of circRNAs in prostate cancer progression.

    In the fields of biomedicine and nanotechnology, scientists also successfully develop [email protected] and HRPS biomimetic nanoparticles that function as high targeting delivery systems for tumor immunotherapy and RA therapy, respectively.

    Scroll down to learn more about the various discoveries and their applications...

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    Research Spotlight – February 2022
  8. A Valentine's gift from us

    Valentine's Day is just around the corner! Check out our science-inspired eCards and share the love this February by sending them to your loved ones, friends, and colleagues.

    See the eCards...
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    A Valentine's gift from us
  9. World Cancer Day 2022

    Today is World Cancer Day. Each year, organizations and people from around the world unite on February 4th to raise awareness about cancer.

    According to the American Cancer Society, cancer mortality had dropped 32% from 1991 to 2019. This decline is mostly attributed to decreases in smoking and advancements in early cancer detection and treatment.

    Despite this reduction in cancer mortality, cancer remains as a major public health problem worldwide. Globally, 1 out of 6 deaths...

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    World Cancer Day 2022
  10. Research Spotlight - January 2022

    We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.

    In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.

    January 2022

    We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.

    In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.

    We have also highlighted several studies discussing novel strategies in nanomedicine to help advance modern healthcare, inc...

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    Research Spotlight - January 2022