Boster Bio Life Science Blog

  1. Research Spotlight - October 2022

    Autumn is here and we’re happy to present our October issue of Research Spotlight!

    This month, we highlight potential therapeutic technologies for treating various disorders. One study developed an exosome-based nanoplatform that enables CRISPR-Cas9 genome-editing therapy for liver diseases.

    Other studies discuss non-drug approaches, such as proper sleeping patterns for preserving hematopoietic stem cell function and diversity, metabolic subtyping for guiding ketogenic therapy i...

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    Research Spotlight - October 2022
  2. 3 Main Types of IHC/ICC Fixatives

    Sample fixation is a required and crucial step for every successful IHC/ICC experiment. Appropriate fixation of samples provides the following benefits during the tissue preparation process:

    • Preserves morphology
    • Prevents tissue degradation
    • Ensures antigenicity
    • Protects cells from damage

    Choosing which fixing solution to use depends...

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  3. Research Spotlight - September 2022

    The September issue of Research Spotlight has arrived! We’re happy to present 10 recent publications from scientists whom Boster has served.

    In this month’s featured publications, scientists highlighted the role of mTORC1 in hyperactive tumors for precision immunotherapy, and investigated the regulatory mechanisms of NF-κB and AMPK/mTOR signaling as therapeutic targets for osteoarthritis and cardiovascular disease, respectively.

    Researchers also explored how resveratrol promotes recovery from spinal cord injury by improving intestinal microbiota. Furthermore, scientists proposed a magnetic soft robotic bladder to help underactive bladders.

    Several nanotherapeutics are introduced, such as TME-responsive MnO2-melittin nanoparticles for enhancing cancer vaccine efficiency, bioactive antibacterial hydromembrane for accelerating diabetic wound healing, and MSC-derived extracellular vesicles for treating brain injury.

    Scroll down to learn more about these discoveries!

    Midkine Expression by Stem-Like Tumor Cells Drives Persistence to mTOR Inhibition and an Immune-Suppressive Microenvironment

    Authors: Tang, Y., Kwiatkowski, D.J., Henske, E.P.
    Journal: Nature Communications

    mTORC1 is hyperactive in multiple cancer types1,2. Here, we performed integrative analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and spatial transcriptomic profiling on Tuberous Sclerosis Complex (TSC) associated tumors with mTORC1 hyperactivity, and identified a stem-like tumor cell state...

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    Cited Boster Product(s): Anti-Cathepsin K/CTSK Antibody Picoband™ (PB9856); Human Midkine ELISA Kit PicoKine® (EK1235)

    Journal Cover

    Magnetic Soft Robotic Bladder for Assisted Urination

    Authors: Yang, Y., Wang, J., Wang, L., Wu, Q., Ling, L., Yang, Y., Ning, S…
    Journal: Science Advances

    The poor contractility of the detrusor muscle in underactive bladders (UABs) fails to increase the pressure inside the UAB, leading to strenuous and incomplete urination. However, existing therapeutic strategies by modulating/ repairing detrusor muscles, e.g., neurostimulation and regenerative medicine, still have low efficacy...

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    Research Spotlight - September 2022
  4. Get 50% OFF of PicoKine® ELISA Kits

    From September 7th to December 16th, you can get 50% off on 400+ PicoKine® ELISA kits! When placing your order for the eligible PicoKine® ELISA kits, submit the promo code 50%ELISA to apply the 50% discount.

    Browse the promoted ELISA kits... and claim your discount. Take advantage of the promotion before it ends!
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    Get 50% OFF of PicoKine® ELISA Kits
  5. How to Determine Antibody Cross-Reactivity

    Choosing the right antibody can get complicated, so it’s not surprising that customers frequently ask us questions like, “If this antibody is validated for human, will it cross-react with rat, too?”

    First, let’s review the concept of cross-reactivity. Cross-reactivity between antigens occurs when an antibody targeted against one specific antigen is successful in binding with another, different antigen. The two antigens in question have similar three-dimensional structural regions, known a...

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    How to Determine Antibody Cross-Reactivity
  6. Research Spotlight - August 2022

    We're happy to present our August issue of Research Spotlight, which highlights potential nano‐therapeutic strategies for targeting several diseases.

    Scientists discussed innovative bio-inspired nanomaterials, such as surfactant functionalized nanorods and bioengineered bacterial outer membrane vesicles to treat K. pneumonia infection and cancer, respectively. Other biomedical studies demonstrated the improved mechanical/therapeutic characteristics of nanoparticles with nano-enzyme activity, e...

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    Research Spotlight - August 2022
  7. Research Spotlight - July 2022

    The July edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

    In this month’s edition, a number of research papers discussed novel approaches for repairing cellular defects upon injury. Zhang et al. explored the regenerative potential of functionalized Schwann-like cells converted from GMSCs for repairing severe PNIs. Other studies highlighted the potential clinical transformation of triboelectric stimulation and DMSO pretreatment to rejuvenate aged BMSCs and preserve male fertility, respectively.

    Several research studies also provided insights for a more effective drug delivery system with a high therapeutic targeting effect using natural compounds. Some examples include using Notoginsenoside R1 for the myocardial-targeting drug delivery system, quercetin to prevent Cd toxicity, and the immunomodulatory effects of different fucoidans.

    Scroll down to learn more about these research discoveries!

    Implantation of a Nerve Protector Embedded With Human GMSC-derived Schwann-Like Cells Accelerates Regeneration of Crush-Injured Rat Sciatic Nerves

    Authors: Zhang, Q., Burrell, J.C., Zeng, J., Motiwala, F.I., Shi, S., Cullen, D.K…
    Journal: Stem Cell Research & Therapy

    Background: Peripheral nerve injuries (PNIs) remain one of the great clinical challenges because of their considerable long-term disability potential. Postnatal neural crest-derived multipotent stem cells, including gingiva-derived mesenchymal stem cells (GMSCs), represent a promising source of seed cells for tissue engineering...

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    Research Spotlight - July 2022
  8. How to Decide ELISA Dilution Ratio

    What is a Dilution Ratio?

    Dilution ratio describes a simple dilution – a unit volume of solute (or sample) is combined with a desired unit volume of solvent (or diluent), to reach a desired total volume (Vsolute + Vsolvent = Total Vsolution)

    Thus, a dilution ratio of 1:4 describes 1 part solute + 4 parts solvent = 5 parts total. The sum of both solute plus solvent equals total, f...

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    elisa-dilution-ratio
  9. How To Perfect Your ELISA Standards

    At Boster, one common question we get from researchers is, “How do I prepare the ELISA standard?” We’re glad you asked because proper construction of the standard curve is the very first step for every ELISA experiment. The standard curve can help confirm that the quality of the kit and the operation procedures are acceptable for further steps.

    For ELISA assays, in order to determine a quantity of something, you need to compare your sample results to a set of standards with known quant...

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    How To Perfect Your ELISA Standards
  10. Research Spotlight - June 2022

    The June issue of Research Spotlight highlights research advancements from scientists whom we have served.

    Read about new studies outlining potential treatments to promote tissue repair and regeneration. For example, one study demonstrated the significance of EE for cardiac repair.

    Scientists also investigated the promising roles of ROS-scavenging hydrogel, responsive Mn3O4 nanoplatform, and a novel 3D-printed porous bioactive ceramic scaffold for spinal cord injury, gastric cancer, and bone injury, respectively.

    Other papers uncovered the molecular mechanisms of SIRT1, Neat1, cathepsin B/NLRP3, and FASN in different diseases and cancer.

    Scroll down to learn more about these 10 research discoveries.

    Environmental Eustress Improves Postinfarction Cardiac Repair via Enhancing Cardiac Macrophage Survival

    Authors: Bai, P.Y., Chen, S.Q., Jia, D.L., Pan, L.H., Liu, C.B., Luo, J.L., Yang, Y…
    Journal: Science Advances

    Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown...

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    Cited Boster Product(s): Mouse BDNF ELISA Kit PicoKine® (EK0309)

    Journal Cover

    Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy

    Authors: Jiang, R.H., Dong, C.J., Chen, Z.L., Cheng, S., Yang, J.X., Gao, W.Y.
    Journal: Oxidative Medicine and Cellular Longevity

    Random-pattern skin flap necrosis limits its application in the clinic. It is still a challenge for plastic surgeons. Catalpol is an effective ingredient extracted from Rehmannia glutinosa, which is reported to promote angiogenesis and protect against ischemic cerebral disease. The aim of our experiment is to assess whether catalpol...

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    Cited Boster Product(s): Anti-VE-Cadherin-5 Cdh5-Antibody Picoband™ (A02632-2)

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    Research Spotlight - June 2022