Transcription factor E2F7 (E2f7)

Atypical E2F transcription factor that participates in a variety of processes such as angiogenesis, polyploidization of cells and DNA damage response. Mainly functions as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'.

Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a crucial role in polyploidization of cells in placenta and liver by regulating the endocycle, likely by repressing genes promoting cytokinesis and antagonizing activity of ancient E2F proteins (E2F1, E2F2 and/or E2F3).