This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Immunoglobulin heavy variable 1-2.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
Human | |
---|---|
Gene Name: | IGHV1-2 |
Uniprot: | P23083 |
Entrez: | 28474 |
Belongs to: |
---|
No superfamily |
Immunoglobulin heavy variable 1-2
Mass (kDA):
13.085 kDA
Human | |
---|---|
Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (105986582..105987019, complement) |
Secreted. Cell membrane.
PMID: 2841108 by Matsuda F., et al. Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.
PMID: 6815656 by Kenten J.H., et al. Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.