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- Table of Contents
Facts about Immunoglobulin heavy variable 1-46.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
Human | |
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Gene Name: | IGHV1-46 |
Uniprot: | P01743 |
Entrez: | 28465 |
Belongs to: |
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No superfamily |
Immunoglobulin heavy variable 1-46
Mass (kDA):
12.933 kDA
Human | |
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Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (106511115..106511552, complement) |
Secreted. Cell membrane.
PMID: 6298778 by Rechavi G., et al. Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups.
PMID: 3084950 by Kojima M., et al. Amino acid sequence of the variable region of heavy chain in immunoglobulin (Mot) having unusual papain cleavage sites.