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- Table of Contents
Facts about Immunoglobulin kappa variable 3-20.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).
Human | |
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Gene Name: | IGKV3-20 |
Uniprot: | P01619 |
Entrez: | 28912 |
Belongs to: |
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No superfamily |
Immunoglobulin kappa variable 3-20
Mass (kDA):
12.557 kDA
Human | |
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Location: | 2p11.2 |
Sequence: | 2; NC_000002.12 (89142574..89143108, complement) |
Secreted. Cell membrane.
PMID: 2997711 by Klobeck H.G., et al. Human immunoglobulin kappa light chain genes of subgroups II and III.
PMID: 3127527 by Kipps T.J., et al. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.