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- Table of Contents
Facts about Immunoglobulin kappa variable 4-1.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins function as receptors which, upon binding of a specific antigen, activate the clonal expansion and differentiation of B lymphocytes to immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector stage of humoral immunity, which causes the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
Human | |
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Gene Name: | IGKV4-1 |
Uniprot: | P06312 |
Entrez: | 28908 |
Belongs to: |
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No superfamily |
Immunoglobulin kappa variable 4-1
Mass (kDA):
13.38 kDA
Human | |
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Location: | 2p11.2 |
Sequence: | 2; NC_000002.12 (88885572..88886153) |
Secreted. Cell membrane.
PMID: 2997712 by Klobeck H.G., et al. Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene.
PMID: 2997713 by Marsh P., et al. Detection of a unique human V kappa IV germline gene by a cloned cDNA probe.