LRRC8B Antibodies

AND LRRC8B ELISA kits, LRRC8B Proteins

Many biological assays use antibodies to detect LRRC8B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRRC8B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRRC8B antibodies...

We validate the specificity of these antibodies to LRRC8B by testing them on tissues known to express LRRC8B positively and negatively. Browse below to find the LRRC8B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRRC8B Infographic by Boster Bio

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LRRC8B (NM_015350) Human Over-expression Lysate

Human

$628
Cat # LS023507
20 µg, 100 µg

LRRC8B Overview

Facts about Volume-regulated anion channel subunit LRRC8B.

LRRC8B 3D structure. Source: alphafold

Volume-regulated anion channel subunit LRRC8B (LRRC8B)

Non-essential part of the volume-regulated anion channel (VRAC, also called VSOAC station ), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes such as taurine.

Channel activity demands LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the exact subunit composition. .

Gene Information

Human
Gene Name:	LRRC8B
Uniprot:	Q6P9F7
Entrez:	23507

Family

Belongs to:

LRRC8 family

Alternative Names

KIAA0231TA-LRRPleucine-rich repeat-containing protein 8B; leucine rich repeat containing 8 family, member B; LRRC8B; MGC42220; R75581; T cell activation leucine repeat rich protein; TALRRP; TA-LRRP; T-cell activation leucine repeat-rich protein

Molecular Weight

Mass (kDA):
92.39 kDA

Genomic Context


Human

Location:	1p22.2
Sequence:	1; NC_000001.11 (89522626..89597861)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane.

Interacting Proteins

LRRC8A

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRRC8B

References

PMID: 22532330 by Abascal F., et al. LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.

PMID: 24790029 by Voss F.K., et al. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.