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- Table of Contents
Facts about Lipolysis-stimulated lipoprotein receptor.
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Human | |
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Gene Name: | LSR |
Uniprot: | Q86X29 |
Entrez: | 51599 |
Belongs to: |
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immunoglobulin superfamily |
ILDR3; immunoglobulin-like domain containing receptor 3; lipolysis stimulated lipoprotein receptor; lipolysis-stimulated lipoprotein receptor; lipolysis-stimulated receptor; lipolysis-stimulated remnant; LISCH protein; LISCH; LISCH7; liver-specific bHLH-Zip transcription factor; LSR; MGC10659; MGC48312; MGC48503
Mass (kDA):
71.439 kDA
Human | |
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Location: | 19q13.12 |
Sequence: | 19; NC_000019.10 (35248656..35267964) |
Cell membrane; Single-pass membrane protein.
If you are looking for a reliable LSR marker, you should check out the Anti-LSR Antibody available from Boster Bio. It is available as catalog number A02742, and reacts with human, mouse, or rat samples. Read on to learn more about Boster Bio and its Anti-LSR Marker. Biological applications of the LSR Marker include assaying aspartate aminotransferase (AST), alanine transaminase (ALT), and lactate dehydrogenase(LDH).
The Boster Bio Anti-LSR Marker is a mouse monoclonal antibody that reacts with Human, Mouse and Rat chylomicrons. The antibody contains Trehalose and is used to detect antibodies to LSR. It is also recommended for use in human studies to identify if antibodies are blocking LSR chylomicrons. The company also produces other products, such as recombinant monoclonal antibodies and knockout edited cell lines, for gold-standard validation.
Several factors contribute to the risk of COVID-19 infection. Although it affects the respiratory system, cardiovascular complications are also possible. In addition to the increased risk of COVID, patients can develop other conditions such as heart failure and atrial fibrillation. The American College of Cardiology published guidelines that will help health care providers manage COVID patients.
Despite the increasing importance of inflammation in arrhythmia diagnosis, it has remained largely understudied. Despite some evidence of their efficacy, there are still no large placebo-controlled studies. This could be due to the lack of large, randomized studies comparing the effects of immune-suppressant drugs. Yet, with the unexpectedly high prevalence of arrhythmic events, researchers have started investigating this issue. Fortunately, there are many patients who have the same systemic inflammation.
The European Association of Preventive Cardiology recommends that physicians use Boster Bio Assay kits for aspartates aminotransferase (ALT) and alanine transaminasase-LDH and other metabolites. In these studies, physicians use the results of these tests to identify high-risk employees and evaluate the risk of death.
Researchers examined a large cohort of chronic COVID patients. More than half were women, with an average age of 48.5 years. They adjusted for age, sex, race, alcohol consumption, and body mass index to examine subgroups based on these factors.
In a multicentre study, Italian researchers estimated that approximately 2.4 per thousand hospitalised COVID-19 patients had myocarditis. Among these patients, one-fifth of those patients had temporary mechanical circulatory support. Most patients recovered without requiring cardiac transplants or other interventions.
A recent Nature Medicine analysis examined outcomes in COVID-19 patients. They compared the risks and excess burden of cardiovascular events among 1000 patients 12 months after the intervention. Inclusion was based on the results of a previous study. Of the 188 patients who were treated with COVID-19, 81 died after the trial. Overall, 81 patients had satisfactory visualization quality.
Researchers found that patients with COVID-19 had worse right ventricular function, a significantly lower tricuspid annular plane systolic excursion, and increased cardiac biomarker concentrations. Even the slightest change in cardiac function may increase the risk of death. Interestingly, COVID patients had more deep venous thrombosis. Other findings included changes in total lung volume and airway resistance. The researchers also found that the disease affected the kidneys' ability to filter waste and excrete carbon dioxide.
In the COVID-19 pandemic, many patients suffer from long-term complications. These are collectively known as "COVID-19 long hauler syndrome." The incidence of ACI in COVID-19 patients is unknown, and the findings may guide patient care. Using this kit can help healthcare providers better understand this complication and predict whether it will return in their patients.
LSR is a cell membrane receptor that may play a key role in the organization of three-cellular tight junctions. The tight-junction proteins are known as receptors for toxins and viruses. These proteins include claudin, which is a membrane receptor for enterotoxin and hepatitis-C virus. LSR is essential for the proper functioning of tight junctions, and it may have implications for their regulation.
To identify the gene that codes for LSR, a 96-well plate was subcloned sequentially with HAP1GT cells. The cells were initially 100 per well, but then were diluted to contain thirty to fifty cells per well, five to fifteen cells per well, and then one cell per plate. The subpopulations were then analyzed by PCR for the presence of gene-trapped LSR clones.
Using a nested PCR procedure, genomic DNA was isolated from five million cells. Primers were designed to recognize the gene-trap insertion. The reverse primers bind to the first intron of the LSR gene. If subpopulations of cells yield PCR products, then the cells belong to the gene-trapped LSR clone. Molecular analyses confirm the presence of gene-trapped LSR.
In another study, we found that mCD inhibits the formation of DRMs by incubating h2-HeLa (h LSR) cells with increasing concentrations of CDTb. mCD inhibits the formation of DRMs, and therefore prevents LSR clustering. Moreover, mCD does not result in the extraction of LSR from membranes. For this study, we used an additional marker called flotillin-2.
Although single-cell RNA-seq is an exciting development, there are still significant challenges to overcome. The community must move from the identification of single genes to functional analysis, visualization, and perturbation. A robust computational framework is needed to minimize these challenges, and can yield informative ranking of candidate multigene marker panels. Our findings are important in guiding future studies. There is a great need for more information about the functions of LSR markers, and we need to take advantage of this opportunity.
Another important consideration in LSR-based markers is the detection of poor-quality markers. These markers can correspond to sub-clusters within a population of interest. In addition, a poor-quality marker could lead to measurement outliers or subpopulations. To overcome this limitation, we developed a novel marker for detecting sub-clusters of interest and reducing false-positive rates. The LSR marker was also successfully applied in a plant breeding study.
PMID: 17693683 by Tang L.-Y., et al. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.