Unconventional myosin-Va Antibodies

AND MYO5A ELISA kits, Unconventional myosin-Va Proteins

Many biological assays use antibodies to detect Unconventional myosin-Va, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Unconventional myosin-Va in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Unconventional myosin-Va antibodies...

We validate the specificity of these antibodies to Unconventional myosin-Va by testing them on tissues known to express MYO5A positively and negatively. Browse below to find the MYO5A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Unconventional myosin-Va? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the MYO5A Western Blot Guide

Designing an IHC experiment for Unconventional myosin-Va? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MYO5A IHC Guide

MYO5A Infographic by Boster Bio

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Anti-MYO5A Antibody Picoband®

Western blot analysis of MYO5A using anti-MYO5A antibody (A02216-2)

IHC analysis of MYO5A using anti-MYO5A antibody (A02216-2)

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A02216-2
100 μg/vial

MYO5A Overview

Facts about Unconventional myosin-Va.

MYO5A 3D structure. Source: alphafold

Unconventional myosin-Va (MYO5A)

Processive actin-based motor that can move in huge steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport.

Also mediates the transport of vesicles into the plasma membrane. May also be required for some polarization process involved in dendrite formation.

Gene Information

Human
Gene Name:	MYO5A
Uniprot:	Q9Y4I1
Entrez:	4644

Family

Belongs to:

TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

Dilute myosin heavy chain, non-muscle; GS1myosin, heavy polypeptide kinase; MYH12myosin-12; MYO5; Myosin heavy chain 12; myosin V; myosin VA (heavy chain 12, myoxin); myosin VA (heavy polypeptide 12, myoxin); Myosin-12; myosin-Va; myoxin; MYR12

Molecular Weight

Mass (kDA):
215.405 kDA

Genomic Context


Human

Location:	15q21.2
Sequence:	15; NC_000015.10 (52307283..52529050, complement)

Tissue Specificity

Detected in melanocytes.

Diseases

Hypopigmentation-immunodeficiency Disease
Immunologic Deficiency Syndromes
Albinism
Nervous System Disorder
Melanoma
Piebaldism
Nervousness
Hypopigmentation Disorder
Malignant Neoplasms
Pigmentation Disorders
Lymphohistiocytosis, Hemophagocytic

Varicosity
Hereditary Diseases
Depressive Disorder
Ataxia
Neoplasms
Melanoma, Experimental

Pathways

Transport
Localization
Melanosome Transport
Pigmentation
Exocytosis
Secretion
Vesicle Transport
Rna Interference
Macrophage Activation
Proteolysis
Cell Migration
Myelination
Pathogenesis

Translation
Intracellular Transport
Insulin Secretion
Mrna Transport
Protein Secretion
Rna Transport
Regulation Of Exocytosis

PTMs

Phosphorylation
Cleavage

Biotinylation
Phosphorothioation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYO5A

References

PMID: 9207796 by Pastural E., et al. Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene.

PMID: 8188282 by Engle L.J., et al. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene.