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- Table of Contents
OCRL Antibodies
AND OCRL ELISA kits, OCRL Proteins
Many biological assays use antibodies to detect OCRL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OCRL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OCRL antibodies...
Designing an IHC experiment for OCRL? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OCRL IHC GuideOCRL Infographic by Boster Bio
All OCRL Products
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OCRL Overview
Facts about Inositol polyphosphate 5-phosphatase OCRL.
Inositol polyphosphate 5-phosphatase OCRL (OCRL)
Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698).
May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976).
Gene Information
| Human | |
|---|---|
| Gene Name: | OCRL |
| Uniprot: | Q01968 |
| Entrez: | 4952 |
Family
| Belongs to: |
|---|
| inositol 1,4,5-trisphosphate 5-phosphatase type II family |
Alternative Names
EC 3.1.3.36; INPP5F; LOCR; Lowe oculocerebrorenal syndrome protein; NPHL2; OCRL1inositol polyphosphate 5-phosphatase OCRL-1; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase
Molecular Weight
Mass (kDA):
104.205 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq26.1 |
| Sequence: | X; NC_000023.11 (129540259..129592556) |
Tissue Specificity
Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium.
Subcellular Localizations
Cytoplasmic vesicle, phagosome membrane. Early endosome membrane. Membrane, clathrin-coated pit. Cell projection, cilium, photoreceptor outer segment. Cell projection, cilium. Cytoplasmic vesicle. Endosome. Golgi apparatus, trans-Golgi network. Lysosome. Also found on macropinosomes (PubMed:25869668). Colocalized with APPL1 on phagosomes (PubMed:22072788).
Diseases
- Oculocerebrorenal Syndrome
- Dent's Disease
- Fanconi Syndrome
- Proteinuria Of Undiagnosed Cause
- Nervousness
- Cataract
- Renal Tubular Disorder
- Multisystem Disorder
- Hypercalciuria
- Kidney Failure
- Muscle Hypotonia
- Acidosis
Interacting Proteins
- CLTC
- Cltc
- Cltc
- PHETA2
- RAB14
- RAB1A
- RAB1B
- RAB5A
- RAB6A
- RAB8A
Pathways
- Localization
- Transport
- Endocytosis
- Cell Proliferation
- Pathogenesis
- Cell Migration
- Phagocytosis
- Secretion
- Cell Division
- Cell Cycle
- Mitosis
- Cytokinesis
- Excretion
PTMs
- Dephosphorylation
- Phosphorylation
Research Areas
- Golgi Apparatus Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OCRL
bosterbio.com/bosterbio-gene-info-cards/OCRL
References
PMID: 1321346 by Attree O., et al. The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase.
PMID: 9048911 by Nussbaum R.L., et al. Physical mapping and genomic structure of the Lowe syndrome gene OCRL1.