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- Table of Contents
Facts about Ryanodine receptor 3.
Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity).
Human | |
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Gene Name: | RYR3 |
Uniprot: | Q15413 |
Entrez: | 6263 |
Belongs to: |
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ryanodine receptor (TC 1.A.3.1) family |
brain ryanodine receptor-calcium release channel; brain-type ryanodine receptor; HBRR; ryanodine receptor 3; RYR-3
Mass (kDA):
552.042 kDA
Human | |
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Location: | 15q13.3-q14 |
Sequence: | 15; NC_000015.10 (33310773..33866121) |
Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.
Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Sarcoplasmic reticulum. The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.
PMID: 9395096 by Nakashima Y., et al. Molecular cloning and characterization of a human brain ryanodine receptor.
PMID: 9515741 by Leeb T., et al. cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene.