SLC12A1 Antibodies

AND SLC12A1 ELISA kits, SLC12A1 Proteins

Many biological assays use antibodies to detect SLC12A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC12A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC12A1 antibodies...

We validate the specificity of these antibodies to SLC12A1 by testing them on tissues known to express SLC12A1 positively and negatively. Browse below to find the SLC12A1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC12A1 Infographic by Boster Bio

All SLC12A1 Products

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Anti-SLC12A1 Antibody Picoband®

1 Q&As

Western blot analysis of SLC12A1 using anti-SLC12A1 antibody (A01106)

IHC analysis of SLC12A1 using anti-SLC12A1 antibody (PB9392)

Human, Monkey, Mouse, Rat

IF, IHC, WB

$370
Cat # PB9392
100 μg/vial

Anti-SLC12A1 Antibody Picoband®

2 Citations 5 Q&As

Western blot analysis of SLC12A1 using anti-SLC12A1 antibody (PA2168)

IHC analysis of SLC12A1 using anti-SLC12A1 antibody (PA2168)

Human, Mouse, Rat

IHC, WB

$370
Cat # PA2168
100 μg/vial

Anti-SLC12A1 / NKCC2 Rabbit Monoclonal Antibody

Western blot analysis of SLC12A1 / NKCC2 expression in K562 cell lysate

Human

$370
Cat # M04473
100 μl/vial

SLC12A1 Overview

Facts about Solute carrier family 12 member 1.

SLC12A1 3D structure. Source: alphafold

Solute carrier family 12 member 1 (SLC12A1)

Electrically silent transporter system. Mediates sodium and chloride reabsorption.

Plays a vital role in the regulation of ionic balance and cell volume. .

Gene Information

Human
Gene Name:	SLC12A1
Uniprot:	Q13621
Entrez:	6557

Family

Belongs to:

SLC12A transporter family

Alternative Names

BSC1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter; MGC48843; NKCC2; NKCC2A variant A; NKCC2Na-K-2Cl cotransporter; SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1

Molecular Weight

Mass (kDA):
121.45 kDA

Genomic Context


Human

Location:	15q21.1
Sequence:	15; NC_000015.10 (48206302..48304078)

Tissue Specificity

Kidney specific.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Bartter Disease
Alkalosis
Metabolic Alkalosis
Gitelman Syndrome
Kidney Diseases
Hypertensive Disease
Polyhydramnios
Diabetes Mellitus
Nephrocalcinosis
Kidney Failure
Premature Birth

Hypercalciuria
Nephrogenic Diabetes Insipidus
Kidney Failure, Chronic
Disease Of Adrenal Medulla
Neoplasms
Diabetes Mellitus, Non-insulin-dependent

Pathways

Transport
Excretion
Secretion
Localization
Insulin Secretion
Diuresis
Pathogenesis
Vasodilation
Chloride Transport
Ion Transport

Loop Of Henle Development
Glomerular Filtration
Senescence
Translation
Kidney Development

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC12A1

References

PMID: 8640224 by Simon D.B., et al. Bartter's syndrome, hypokalemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2.

PMID: 21613606 by Cruz-Rangel S., et al. Similar Effects of all WNK3 Variants upon SLC12 Cotransporters.