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- Table of Contents
UBR5 Antibodies
AND UBR5 ELISA kits, UBR5 Proteins
Many biological assays use antibodies to detect UBR5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBR5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBR5 antibodies...
Designing a Western blot for UBR5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the UBR5 Western Blot GuideUBR5 Infographic by Boster Bio
All UBR5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03160-1
100 μg/vial
Cat # A03160-1
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1179
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1179
1 kit, containing one 96-well plate and all necessary reagents
UBR5 Overview
Facts about E3 ubiquitin-protein ligase UBR5.
E3 ubiquitin-protein ligase UBR5 (UBR5)
E3 ubiquitin-protein ligase which is a part of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, resulting in their ubiquitination and subsequent degradation (By similarity).
Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBR5 |
| Uniprot: | O95071 |
| Entrez: | 51366 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DD5; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase, HECT domain-containing 1; EC 6.3.2; EC 6.3.2.-; EDD; EDD1; EDD1E3 ubiquitin-protein ligase UBR5; EDDE3 identified by differential display; hHYD; HYD; HYDFLJ11310; Hyperplastic discs protein homolog; KIAA0896MGC57263; progestin induced protein; Progestin-induced protein; ubiquitin protein ligase E3 component n-recognin 5; ubiquitin-protein ligase; UBR5
Molecular Weight
Mass (kDA):
309.352 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q22.3 |
| Sequence: | 8; NC_000008.11 (102252273..102412700, complement) |
Tissue Specificity
Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Hyperplasia
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Liver Carcinoma
- Allelic Imbalance
- Stomach Neoplasms
- Malignant Neoplasm Of Tongue
Interacting Proteins
- CTNNB1
- GSK3B
- PAIP2
Pathways
- Proteolysis
- Translation
- Cell Cycle
- Cell Proliferation
- Dna Damage Checkpoint
- Rna Interference
- Gluconeogenesis
- Cell Death
- Ras Protein Signal Transduction
- Transport
- Cell Cycle Arrest
- Carbon Dioxide Transport
- Water Transport
PTMs
- Ubiquitination
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBR5
bosterbio.com/bosterbio-gene-info-cards/UBR5
References
PMID: 10030672 by Callaghan M.J., et al. Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs.
PMID: 11714696 by Honda Y., et al. Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.