BRISC complex subunit Abraxas 2 (ABRAXAS2)

Component of the BRISC complicated, a multiprotein complex that specifically cleaves'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein which assembles the various components of the BRISC complicated and keeps them in the cytoplasm (PubMed:20656690).

Plays a role in regulating the onset of apoptosis via its role in regulating'Lys- 63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).