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- Table of Contents
Facts about Disintegrin and metalloproteinase domain-containing protein 19.
May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). .
Human | |
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Gene Name: | ADAM19 |
Uniprot: | Q9H013 |
Entrez: | 8728 |
Belongs to: |
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No superfamily |
a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM 19; ADAM metallopeptidase domain 19; ADAM19; disintegrin and metalloproteinase domain-containing protein 19; EC 3.4.24; EC 3.4.24.-; MADDAM; Meltrin beta; meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MLTNBmeltrin beta
Mass (kDA):
104.997 kDA
Human | |
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Location: | 5q33.3 |
Sequence: | 5; NC_000005.10 (157477304..157575775, complement) |
Expressed in many normal organ tissues and several cancer cell lines.
Membrane; Single-pass type I membrane protein.
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The ADAM19 marker, which is an anchoring glycoprotein on the membrane that is part of the family of cytokines, can detect neuregulin isotypes. ADAMs play a key role in myoblast formation, neurogenesis fertilization, and other processes. Meltrin B, which is one of the members of the ADAM family, is involved in the processing of proteolytically processed NRGs that are anchored to membranes. In cell culture, NRG-1 was processed and released into the medium of culture.
There are a variety of members of the Neuregulin family each with distinct functions. The most well-studied neuregulin 1 is a neurotrophin like protein involved in a variety of functions of the nervous system. The NH2-terminal regions of neuregulin 1 distinguish it from other members of the neuregulin family. The family is comprised of three types of NRGs: type I, type II NRG1, and type III NRG1.
The NRG1 and NRG2 are both type I transmembrane proteins. The NRG1 and NRG2 are extremely homologous, with the NRG2 isoform sharing the highest degree of homology. Extracellular NRG2 is a single EGF-like domain that is responsible for binding ErbB receptors. They also have an Ig domain, which is thought to regulate interactions with extracellular matrix proglycans. Furthermore, the NRG1 gene encodes numerous splice variants.
The trafficking of neuregulin from degradative compartments is controlled by the cell protein Nrdp1. This protein is abundant in adult tissues and is in line with its role in the process of signaling neuregulin in development and maintenance. What is the way this protein function in the body? The following article will discuss different pathways. Below are a few targets for neuregulin signaling.
The neuregulin receptor target is known to show diminished down-regulation, degradation and internalization. The changes in neuregulin receptor levels could be the result of a reduction in the target protein. This mechanism may also contribute to neuregulin's signaling activity. The question is "How does neuregulin regulate other proteins?"
Boster Bio is an antibody manufacturer that is specialized in picogram sensitivity ELISA kits and IHC-optimized monoclonal antibodies. The Boster Bio product line contains more than 12,000 antibodies and has been validated using a panel of 250 tissues. They also perform rigorous quantitative validation by testing their antibodies against known recombinant proteins , as well as untransfected cells. Technical support by Boster will further increase the antibody's specificity as as high affinity.
In addition to this study A different company is also involved in the process of producing neuregulin. The company also supplies ERBB with the ectodomain neuregulin. These proteins are vital for neuregulin-mediated myelination. Hence, altered neuregulin levels can contribute to the pathologies that are associated with human DPN. This product is anticipated to provide significant benefits to patients suffering from neurodegenerative diseases, such as Alzheimer's disease.
Despite its positive effects on cancer cells, Nrdp1 has been shown to inhibit Neuregulin signaling. NRG1b stimulation in MCF7 cells results in an ‘all-or-nothing’ reaction. HA-tagged Erk1 is the downstream resultant of neuregulin stimulation. After increasing the concentration of NRG1b, cells were removed from the body. The cells were immunoblotted using antiphospho-Erk1/2 antibodies.
The family of Neuregulins is a diverse collection of proteins that regulate cell-based events. Neuregulin-1 is among the most researched of these proteins. It is also known by various other names, for instance, glial growth factors or acetylcholine receptor-inducing actions. It is also important in the development of the cardiac and neural tissues. These proteins are heterodimerized and bind to the ErbB2 receptors.
PMID: 10887142 by Fritsche J., et al. Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation.
PMID: 11162584 by Wei P., et al. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta.