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- Table of Contents
AFG3-like protein 2 Antibodies
AND AFG3L2 ELISA kits, AFG3-like protein 2 Proteins
Many biological assays use antibodies to detect AFG3-like protein 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AFG3-like protein 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AFG3-like protein 2 antibodies...
Designing a Western blot for AFG3-like protein 2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AFG3L2 Western Blot GuideAFG3L2 Infographic by Boster Bio
All AFG3L2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # PB9915
100 μg/vial
Cat # PB9915
100 μg/vial
Human, Mouse, Rat
WB
$523
Cat # M04820
100 µl
Cat # M04820
100 µl
AFG3L2 Overview
Facts about AFG3-like protein 2.
AFG3-like protein 2 (AFG3L2)
ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complicated, limiting the access to SMDT1/EMRE for MCU assembly and encouraging efficient assembly of gatekeeper subunits with MCU (PubMed:27642048).
Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | AFG3L2 |
| Uniprot: | Q9Y4W6 |
| Entrez: | 10939 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AFG3 (ATPase family gene 3, yeast)-like 2; AFG3 ATPase family gene 3-like 2 (S. cerevisiae); AFG3 ATPase family gene 3-like 2 (yeast); AFG3-like protein 2; ATPase family gene 3, yeast; EC 3.4.24; EC 3.4.24.-; FLJ25993; Paraplegin-like protein; SCA28; spinocerebellar ataxia 28
Molecular Weight
Mass (kDA):
88.584 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18p11.21 |
| Sequence: | 18; NC_000018.10 (12328944..12377309, complement) |
Tissue Specificity
Ubiquitous. Highly expressed in the cerebellar Purkinje cells.
Subcellular Localizations
Mitochondrion. Mitochondrion inner membrane; Multi-pass membrane protein.
Diseases
- Ataxia
- Neurodegenerative Disorders
- Ataxia, Spinocerebellar
- Paraplegia
- Spastic Paraplegia
- Spastic Paraplegia, Hereditary
- Aortic Aneurysm, Abdominal
- Cerebellar Diseases
- Nerve Degeneration
- Cerebellar Ataxia
- Spinocerebellar Degeneration
- Atrophy
Pathways
- Pathogenesis
- Mitochondrial Fusion
- Ribosome Assembly
- Localization
- Translation
- Cell Death
- Mitochondrial Unfolded Protein Response
- Proteolysis
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AFG3L2
bosterbio.com/bosterbio-gene-info-cards/AFG3L2
References
PMID: 10395799 by Banfi S., et al. Identification and characterization of AFG3L2, a novel paraplegin- related gene.
PMID: 14623864 by Atorino L., et al. Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia.