A-kinase anchor protein 10, mitochondrial (AKAP10)

Differentially targeted protein which binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological significance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA.

It can't be excluded too that it may facilitate PKA in addition to G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it might lead to the interaction to G-alpha proteins, providing a connection between the signaling machinery and the downstream kinase (By similarity).