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- Table of Contents
Facts about A-kinase anchor protein 10, mitochondrial.
It can't be excluded too that it may facilitate PKA in addition to G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it might lead to the interaction to G-alpha proteins, providing a connection between the signaling machinery and the downstream kinase (By similarity).
Human | |
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Gene Name: | AKAP10 |
Uniprot: | O43572 |
Entrez: | 11216 |
Belongs to: |
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No superfamily |
A kinase (PRKA) anchor protein 10; AKAP-10; A-kinase anchor protein 10, mitochondrial; D-AKAP2; D-AKAP-2; Dual specificity A kinase-anchoring protein 2; dual-specificity A-kinase anchoring protein 2; MGC9414; mitochondrial A kinase PPKA anchor protein 10; PRKA10a kinase anchor protein 10, mitochondrial; protein kinase A anchoring protein 10; Protein kinase A-anchoring protein 10
Mass (kDA):
73.818 kDA
Human | |
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Location: | 17p11.2 |
Sequence: | 17; NC_000017.11 (19904302..19977856, complement) |
Mitochondrion. Membrane. Cytoplasm. Predominantly mitochondrial but also membrane associated and cytoplasmic.
PMID: 11248059 by Wang L., et al. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein.
PMID: 17485678 by Tingley W.G., et al. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.