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- Table of Contents
APPL1 Antibodies
AND APPL1 ELISA kits, APPL1 Proteins
Many biological assays use antibodies to detect APPL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APPL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APPL1 antibodies...
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APPL1 Infographic by Boster Bio
All APPL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02381
100 μg/vial
Cat # A02381
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M02381
100 μg/vial
Cat # M02381
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02381-1
100 μl/vial
Cat # M02381-1
100 μl/vial
APPL1 Overview
Facts about DCC-interacting protein 13-alpha.
DCC-interacting protein 13-alpha (APPL1)
Adapter protein that interacts with proteins involved in various cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment.
Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | APPL1 |
| Uniprot: | Q9UKG1 |
| Entrez: | 26060 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zippercontaining 1; AKT2 interactor; APPL; APPL1; APPLdip13-alpha; DCC-interacting protein 13-alpha; DIP 13 alpha; DIP13A; DIP13alpha; Dip13-alpha; KIAA1428; signaling adaptor protein DIP13alpha
Molecular Weight
Mass (kDA):
79.663 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p14.3 |
| Sequence: | 3; NC_000003.12 (57227729..57273471) |
Tissue Specificity
High levels in heart, ovary, pancreas and skeletal muscle.
Subcellular Localizations
Early endosome membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endosome. Cell projection, ruffle. Cytoplasmic vesicle, phagosome. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Diseases
- Insulin Resistance
- Diabetes Mellitus
- Obesity
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Sensitivity
- Oculocerebrorenal Syndrome
- Inflammation
- Nervousness
- Dent's Disease
- Malignant Neoplasms
- Hyperglycemia
Interacting Proteins
- ACTN2
- ADIPOR1
- Adipor1
- ADIPOR2
- AKT1
- APPL2
- DST
- DYSF
- EGFR
- FARS2
Pathways
- Endocytosis
- Localization
- Transport
- Secretion
- Cell Proliferation
- Glucose Transport
- Vasodilation
- Insulin Secretion
- Energy Homeostasis
- Rna Interference
- Clathrin-mediated Endocytosis
- Gluconeogenesis
- Sensitization
PTMs
- Phosphorylation
- Oxidation
- Nitration
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APPL1
bosterbio.com/bosterbio-gene-info-cards/APPL1
References
PMID: 10490823 by Mitsuuchi Y., et al. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
PMID: 12011067 by Liu J., et al. Mediation of the DCC apoptotic signal by DIP13 alpha.