Autism susceptibility gene 2 protein (AUTS2)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class necessary to keep the transcriptionally repressive state of several genes, such as Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132).

The PRC1-like complex which contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132).