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- Table of Contents
Axin-2 Antibodies
AND AXIN2 ELISA kits, Axin-2 Proteins
Many biological assays use antibodies to detect Axin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Axin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Axin-2 antibodies...
Designing a Western blot for Axin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AXIN2 Western Blot GuideDesigning an IHC experiment for Axin-2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the AXIN2 IHC GuideAXIN2 Infographic by Boster Bio
All AXIN2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01772-2
100 μg/vial
Cat # A01772-2
100 μg/vial
Anti-Axin2/Conductin Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01772
100 μl
Cat # M01772
100 μl
AXIN2 Overview
Facts about Axin-2.
Axin-2 (AXIN2)
Inhibitor of the Wnt signaling pathway.
Down-regulates beta-catenin.Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | AXIN2 |
| Uniprot: | Q9Y2T1 |
| Entrez: | 8313 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AXIL; axin 2; Axin2; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Molecular Weight
Mass (kDA):
93.558 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q24.1 |
| Sequence: | 17; NC_000017.11 (65528563..65561648, complement) |
Tissue Specificity
Expressed in brain and lymphoblast.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Colorectal Cancer
- Cell Transformation, Neoplastic
- Polyposis
- Colorectal Neoplasms
- Adenomatous Polyposis Coli
- Congenital Absence
- Carcinogenesis
- Hypodontia
- Malignant Tumor Of Colon
- Colonic Neoplasms
Interacting Proteins
- AMER3
- CTNNB1
- PLK1
- PPP2CB
- TGIF1
Pathways
- Cell Proliferation
- Localization
- Segmentation
- Cell Growth
- Pathogenesis
- Mismatch Repair
- Regeneration
- Cell Cycle
- Somitogenesis
- Methylation
- Cell Differentiation
- Odontogenesis
- Rna Interference
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Sumoylation
- Biotinylation
Research Areas
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AXIN2
bosterbio.com/bosterbio-gene-info-cards/AXIN2
References
PMID: 10049590 by Mai M., et al. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24.
PMID: 11017067 by Liu W., et al. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.