BBS12 Antibodies

AND BBS12 ELISA kits, BBS12 Proteins

Many biological assays use antibodies to detect BBS12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BBS12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BBS12 antibodies...

We validate the specificity of these antibodies to BBS12 by testing them on tissues known to express BBS12 positively and negatively. Browse below to find the BBS12 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BBS12 Infographic by Boster Bio

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BBS12 Overview

Facts about Bardet-Biedl syndrome 12 protein.

BBS12 3D structure. Source: alphafold

Bardet-Biedl syndrome 12 protein (BBS12)

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis.

As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.

Gene Information

Human
Gene Name:	BBS12
Uniprot:	Q6ZW61
Entrez:	166379

Family

Belongs to:

TCP-1 chaperonin family

Alternative Names

Bardet-Biedl syndrome 12; chromosome 4 open reading frame 24; FLJ35630C4orf24Bardet-Biedl syndrome 12 protein; FLJ41559

Molecular Weight

Mass (kDA):
79.085 kDA

Genomic Context


Human

Location:	4q27
Sequence:	4; NC_000004.12 (122700437..122744943)

Subcellular Localizations

Cell projection, cilium. Located within the basal body of the primary cilium of differentiating preadipocytes.

Diseases

Bardet-biedl Syndrome
Obesity
Polydactyly
Retinitis Pigmentosa
Diabetes Mellitus
Dystrophy
Retinal Degeneration
Kidney Diseases
Retinal Dystrophies
Learning Disabilities
Impaired Cognition

Hypertensive Disease
Hereditary Diseases
Hypogonadism
Congenital Heart Defects
Moderate Mental Retardation
Atresia

Interacting Proteins

BBS10
BBS7
BBS9
MKKS

Pathways

Transport
Cell Cycle
Neurogenesis
Pigmentation
Pathogenesis
Protein Transport
Membrane Biogenesis

Inflammatory Response

Research Areas

Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BBS12

References

PMID: 19190184 by Marion V., et al. Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation.

PMID: 20080638 by Seo S., et al. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.