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- Table of Contents
Septin-9 Antibodies
AND SEPTIN9 ELISA kits, Septin-9 Proteins
Many biological assays use antibodies to detect Septin-9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Septin-9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Septin-9 antibodies...
Designing an IHC experiment for Septin-9? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SEPTIN9 IHC GuideSEPTIN9 Infographic by Boster Bio
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All SEPTIN9 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A05279-3
100 μg/vial
Cat # A05279-3
100 μg/vial
SEPTIN9 Overview
Facts about Septin-9.
Septin-9 (SEPTIN9)
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
May play a role in the internalization of two intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SEPTIN9 |
| Uniprot: | Q9UHD8 |
| Entrez: | 10801 |
Family
| Belongs to: |
|---|
| TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily |
Alternative Names
Septin-9
Molecular Weight
Mass (kDA):
65.401 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (77281499..77500596) |
Tissue Specificity
Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.
Subcellular Localizations
Cytoplasm, cytoskeleton. In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Interacting Proteins
- HIF1A
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEPTIN9
bosterbio.com/bosterbio-gene-info-cards/SEPTIN9
References
PMID: 10339604 by Osaka M., et al. MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).
PMID: 10987277 by Russell S.E.H., et al. Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.