Brevican core protein Antibodies

Brevican core protein (Bcan)

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

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Gene Information

Mouse
Gene Name:	Bcan
Uniprot:	Q61361
Entrez:	12032

Family

Belongs to:
aggrecan/versican proteoglycan family

Alternative Names

ALPBRE; BCAN; BEHAB; BEHABbrevican core protein; Brain-enriched hyaluronan-binding protein; Brevican; Chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; chondroitin sulfate proteoglycan BEHAB/brevican; CSPG7; CSPG7brevican proteoglycan; MGC13038

Molecular Weight

Mass (kDA):
95.815 kDA

Genomic Context

Mouse
Location:	3 F1|3 38.78 cM
Sequence:	3;

Tissue Specificity

Brain.

Diseases

• Nervousness
• Neoplasms
• Glioma
• Brain Neoplasms
• Malignant Neoplasms
• Cell Invasion
• Neoplasm Invasiveness
• Tissue Adhesions
• Malignant Paraganglionic Neoplasm
• Neoplasm Metastasis
• Brain Injuries
• Gliosis
• Injury Of Central Nervous System

• Bladder Neoplasm
• Brain Tumor, Primary
• Malignant Neoplasm Of Urinary Bladder
• Malignant Glioma
• Spinal Cord Injuries
• Headache
• Glioblastoma

Pathways

• Localization
• Brain Development
• Cell Adhesion
• Regeneration
• Cell Motility
• Axon Regeneration
• Axon Guidance
• Cell Proliferation
• Synaptic Transmission
• Tissue Remodeling
• Secretion
• Transport
• Cell Activation

• Cell Migration
• Aging
• Proteolysis
• Glial Cell Proliferation
• Neurogenesis
• Ossification
• Myelination

PTMs

• Cleavage

• Glycosylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Bcan

Best Uses Of The BCAN Marker From Boster Bio

Boster Bio provides several markers for scientists. These include the IL6 marker, CD2 marker, AQP3 antibody, and anti-CD68 antibody. Boster offers product credits for scientists who submit samples, applications, and species results. Boster also offers a software platform that is easy to use for scientists around world. This article will provide a brief description for each product and the purpose it serves.

Boster Bio's ILP marker

Boster Bio has demonstrated that the IL6 marker from Boster Bio is superior in diagnosing and prognosticating when used to assess effectiveness of antibiotic therapy. This marker is most useful for measuring the body's response to antibiotics. Healthcare professionals recommend that it be used in conjunction with other tests. A panel of independent experts rated the accuracy of the report, and divided the subjects into two groups. Light's Kappa stood at 0.837.

The study also revealed that IL-6 levels were associated with respiratory disease. The cytokine can be produced by the lungs and is linked to respiratory failure. This may explain the association between IL-6 levels and the need for oxygen. A preliminary report is generated 72 hours after the sample is collected and a final report is generated 120 hours later. The three-way interpretation of the results is that the researchers assess the blood IL-6 levels and determine if disease-causing cells are inflamed.

IL-6 can be described as a pleiotropic a–helical cytokine. It has multiple functions. It stimulates production of acute phase protein, inhibits formation of albumin, regulates innate immune system and acquired immunity. IL-6 is also involved in various physiological processes such as the development of Th27 cells, regulation of bone metabolism, and regulation of blood glucose metabolism. This cytokine might be an important contributor to many diseases in the future.

Boster Bio's CD2 marker

The CD2 mark is a single pass membrane protein that interacts several molecules, including CD58/BCM1, the lymphocyte function as-associated antigen CD58/BCM1. Boster Bio's tool will help you learn more about its role in activating T-cells as well as signaling function. Boster Bio's CD2 markers are able to detect cancer and provide optimization guides that can be used to aid in research.

In-depth analysis of the structure of CD2 was done. It also contains an IgM molecular and a transmembrane loop. These molecules can bind to specific CD2 residues, facilitating cell-to–cell communication. Li et al. (27) discovered a series residues on CD2 serving as GYF binding motifs. #1 is the binding site to Fyn Kinase.

CD2 is a cell surface glycoprotein found on most human T and NK cells. It has also been known as T cell surface antigen (T11/Leu-5) It is a member the immunoglobulin superfamily. It contains two immunoglobulin-like domains in the extracellular region, and interacts with lymphocyte function-associated antigen-3, which is expressed by antigen-presenting cells. The CD2/CD58 interaction promotes cell contact and facilitates activation of the T-cell receptor. CD2 is a useful marker that can be used to identify NK and T cells in different contexts.

Boster Bio's AQP3 marker

The AQP3 gene can be expressed in a variety of human cell types. Researchers can quantitatively measure protein and mRNA levels within cells using the AQP3 markers. This study confirmed previous findings. Bioinformatics was used to study the mechanisms of AQP3 gene expression.

Previous research has shown a link between AQP3 and increased expressions of CD44 in GC-cells. The authors suggested that AQP3 may control the expressions of CD44 and bcatenin within GC cells. The AQP3 gene is positively correlated in 86 markers related to cell proliferation and metastasis. These findings suggest that AQP3 is involved in tumorigenesis.

AQP3 is found in the cell membranes of trophoblasts throughout embryo development. It also supports adhesion to the endometrium. Its expression level in non-pregnanttrophoblasts is not known. AQP3 has a significant role in the development phase of an embryo during human reproduction. The protein's disruption has been shown to affect 311 genes via gene expression microarrays. These genes are involved with angiogenesis, cell movement and extracellular matrix recombination.

AQP3 (water/glycerol transporting proteins) is expressed at a high level in keratinocytes. It facilitates water/glycerol transportation and proliferation. In this study, AQP3 was expressed in keratinocytes cultured under high Ca2+, 1a,25-vitaminD3 conditions to induce differentiation. It was interesting to note that the expression of differentiation markers proteins was similar between AQP3 knockout keratinocytes and control.

Boster Bio has developed an anti-CD68 antibody

Boster Bio's anti-CD68 monoclonal antibody uses the BCAN marker to recognize granular cell tumors. The antibody is non-hazardous and can be used for a wide variety of applications, including immunohistochemistry (IHC). The company provides blocking peptides at various concentrations to minimize contamination. The price of blocking drugs varies depending on how long the immunogen is and how much it is required.

CD68 is a 110kDa single chain glycoprotein expressed on macrophages. Human and mouse CD68 are largely expressed on macrophages, which are the cell types that produce the body's immune cells. The BCAN marker can help differentiate between different types of macrophages. Antibodies to CD68 can also be used to distinguish between lymphocytes and macrophages.

Boster Bio has developed an anti-CD73 antibody

Anti-CD73 antibody works by activating the immune checkpoint in the body. It has been shown, through antibody-mediated immunocheckpoint inhibition, to inhibit tumor cell proliferation by increasing leukocyte number and secretion TH2 cytokines. The antibody can also tested in cells containing purified CD4+-lymphocytes. Boster Bio's anti CD73 antibody uses a BCAN mark to detect tumor cells.

CD73 is a multifunctional, multifunctional protein. It has multiple functions in cells. It is responsible for AMP Hydrolysis, which produces adenosine. CD73 generates adenosine, which plays a crucial role in tumor immunoescape. It also acts as an adhesive and signal molecule, which interacts with extracellular matrix elements. These functions may not be completely independent, but the anti-CD73 antigen shows enhanced synergy when combined with anti-PD-1 mAbs or anti-CTLA-4 mAbs.

Boster Bio's anti-CD73 monoclonal antibody is capable of targeting ectoenzyme 5'-ecto-nucleotidase. This antibody blocks CD73's activity by blocking this enzyme. This antibody also decreases activity of myeloid suppressor cells. It also increases the production of CD8 positive effector cells and inhibits myeloid-derived suppressor cell activity.

Boster Bio developed this antibody. It is based in part on purified 3F7 antibodies. It induces expression maturation markers as well as morphological transform into plasmablasts. Additionally, it increases secretion of IgM and IgG. It also stimulates the growth and expansion of new clones of B cells. The antibody targets B cells that express BCAN.

Boster Bio has developed an anti-CD40 anti-CD40 antibody

The BCAN marker can be used to identify CD40 human mAbs. The BCAN marker in CD40 antibodies can be used for identification of a cell type or confirmation of antigen specificity. A variety of screening assays can be used to identify antibodies that are useful. ELISA measures antigen specificity by coating a microplate containing the immunogen of concern. To detect binding of the antibody, an additional antibody is used that is specific for the Ig species. In vitro and in-vitro functional assays, as well as neutralizing tests, are used to screen for antibodies.

The antigen contained within the antibody contains two pieces: a fragment of the light chain variable region (20-132) and a fragment of heavy chain variable regions (23-128). The sequence 23-128 amino acids of SEQ ID no. 1 defines the light chains variable region. The antibody contains the BCAN marker as well as the humanized form.

The important signaling molecule CD40 has been implicated in autoimmune disorders. Studies have shown CD40-bearing T cell can inhibit the growth other immune cells including those fighting tumors. It has also been proven that anti-CD40 antibodies can stimulate production of T-cells and B-cells in the body.