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- Table of Contents
Facts about Bridging integrator 2.
Plays a role in podosome formation. Inhibits phagocytosis.
Human | |
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Gene Name: | BIN2 |
Uniprot: | Q9UBW5 |
Entrez: | 51411 |
Belongs to: |
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No superfamily |
BRAP1; BRAP-1; breast cancer associated protein BRAP1; Breast cancer-associated protein 1; bridging integrator 2; bridging integrator-2
Mass (kDA):
61.874 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (51281038..51324668, complement) |
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.
PMID: 10903846 by Ge K., et al. Bin2, a functionally nonredundant member of the BAR adaptor gene family.
PMID: 23285027 by Sanchez-Barrena M.J., et al. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.