Bactericidal permeability-increasing protein (BPI)

The cytotoxic activity of BPI is limited to a lot of species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very fundamental N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.

aeruginosa, this activity is inhibited by LPS from P.aeruginosa.