- Table of Contents
We validate the specificity of these antibodies to Calsequestrin-1 by testing them on tissues known to express CASQ1 positively and negatively. Browse below to find the CASQ1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about Calsequestrin-1.
Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the discharge of lumenal Ca(2+) through the calcium release channel RYR1; this plays an significant role in triggering muscle contraction.
calmitin; calmitine; calsequestrin 1 (fast-twitch, skeletal muscle); Calsequestrin, skeletal muscle isoform; calsequestrin-1; CASQ; PDIB1
|Sequence:||1; NC_000001.11 (160190575..160201886)|
Expressed in myoblasts (at protein level).
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244). In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244). Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellula