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- Table of Contents
Facts about Carbonyl reductase [NADPH] 1.
Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.
| Human | |
|---|---|
| Gene Name: | CBR1 |
| Uniprot: | P16152 |
| Entrez: | 873 |

| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |

15-hydroxyprostaglandin dehydrogenase [NADP+]; carbonyl reductase (NADPH) 1; carbonyl reductase (NADPH) 1, EC 1.1.1.18410EC 1.1.1.197,15-hydroxyprostaglandin dehydrogenase; carbonyl reductase [NADPH] 1; carbonyl reductase 1; CBR; CRN; EC 1.1.1.184; EC 1.1.1.189; hCBR1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; SDR21C1; short chain dehydrogenase/reductase family 21C, member 1
Mass (kDA):
30.375 kDA

| Human | |
|---|---|
| Location: | 21q22.12 |
| Sequence: | 21; NC_000021.9 (36070024..36073164) |
Cytoplasm.





PMID: 3141401 by Wermuth B., et al. Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.
PMID: 2182121 by Forrest G.L., et al. Induction of a human carbonyl reductase gene located on chromosome 21.