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- Table of Contents
1 Q&As
Facts about ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial.
Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding action of TFAM and is necessary for maintaining a typical mitochondrial nucleoid structure (PubMed:22841477).
| Human | |
|---|---|
| Gene Name: | CLPX |
| Uniprot: | O76031 |
| Entrez: | 10845 |

| Belongs to: |
|---|
| ClpX chaperone family |

ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ClpX caseinolytic peptidase X homolog (E. coli); ClpX caseinolytic protease X homolog; energy-dependent regulator of proteolysis
Mass (kDA):
69.224 kDA

| Human | |
|---|---|
| Location: | 15q22.31 |
| Sequence: | 15; NC_000015.10 (65148219..65185374, complement) |
Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.





PMID: 11003706 by Corydon T.J., et al. Human and mouse mitochondrial orthologs of bacterial ClpX.
PMID: 11923310 by Kang S.G., et al. Functional proteolytic complexes of the human mitochondrial ATP- dependent protease, hClpXP.