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Coatomer subunit zeta-1 Antibodies
AND COPZ1 ELISA kits, Coatomer subunit zeta-1 Proteins
Many biological assays use antibodies to detect Coatomer subunit zeta-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coatomer subunit zeta-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coatomer subunit zeta-1 antibodies...
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COPZ1 Infographic by Boster Bio
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COPZ1 Overview
Facts about Coatomer subunit zeta-1.
Coatomer subunit zeta-1 (COPZ1)
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | COPZ1 |
| Uniprot: | P61923 |
| Entrez: | 22818 |
Family
| Belongs to: |
|---|
| adaptor complexes small subunit family |
Alternative Names
Coatomer subunit zeta-1
Molecular Weight
Mass (kDA):
20.198 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (54325109..54351850) |
Subcellular Localizations
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPZ1
bosterbio.com/bosterbio-gene-info-cards/COPZ1
References
PMID: 11056392 by Futatsumori M., et al. Identification and characterization of novel isoforms of COP I subunits.
PMID: 19167404 by Yu W., et al. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats.