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Coronin-1C Antibodies
AND CORO1C ELISA kits, Coronin-1C Proteins
Many biological assays use antibodies to detect Coronin-1C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coronin-1C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coronin-1C antibodies...
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CORO1C Infographic by Boster Bio
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CORO1C Overview
Facts about Coronin-1C.
Coronin-1C (CORO1C)
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the existence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950).
Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, resulting in recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460).
Gene Information
| Human | |
|---|---|
| Gene Name: | CORO1C |
| Uniprot: | Q9ULV4 |
| Entrez: | 23603 |
Family
| Belongs to: |
|---|
| WD repeat coronin family |
Alternative Names
coronin 1C; coronin, actin binding protein, 1C; coronin, actin-binding protein, 1C; coronin-1C; Coronin-3; CRNN4; HCRNN4
Molecular Weight
Mass (kDA):
53.249 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.11 |
| Sequence: | 12; NC_000012.12 (108645109..108759955, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Endosome membrane. All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:302204
Diseases
- Malignant Neoplasms
- Neoplasm Metastasis
- Melanoma
- Tumor Progression
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Glioma
- Carotid Artery Injuries
- Sarcoma
- Vascular System Injuries
- Tumor Angiogenesis
- Primary Effusion Lymphoma
Interacting Proteins
- CORO1B
Pathways
- Cell Motility
- Cell Adhesion
- Regeneration
- Chemotaxis
- Cell Migration
- Cell Cycle
- Brain Development
- Interphase
- Angiogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CORO1C
bosterbio.com/bosterbio-gene-info-cards/CORO1C
References
PMID: 10828594 by Iizaka M., et al. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins.
PMID: 19651142 by Xavier C.P., et al. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle.