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- Table of Contents
Facts about Casein kinase II subunit alpha'.
May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular reaction. During mitosis, functions as a part of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 action and G2 arrest in response to spindle damage.
Human | |
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Gene Name: | CSNK2A2 |
Uniprot: | P19784 |
Entrez: | 1459 |
Belongs to: |
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protein kinase superfamily |
casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha'; CK II alpha'; CK2A2; CSNK2A1; EC 2.7.11; EC 2.7.11.1; FLJ43934
Mass (kDA):
41.213 kDA
Human | |
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Location: | 16q21 |
Sequence: | 16; NC_000016.10 (58157907..58198106, complement) |
What is the CSNK2A2 Marker? What can it do for your research? We'll explore this and other topics in Steven Boster's bio. You'll also learn more about its sources and applications. Boster Bio: Best Uses Of The CSNK2A2 Marker
The CSNK2A2 gene is a protein that encodes the catalytic subunit of CK2. The CK2a kinase is highly expressed in GBMs and is a common gene mutation in many other cancers. CK2 is known to regulate tumor cell growth and survival and DNA repair following ionizing radiation. Its inhibition is known to alter the growth of glioma cell lines and slow the growth of GBM xenografts in immunodeficient mice.
Several studies have linked the CSNK2A2 marker with telomere length. However, in other studies, there are no clear associations between CSNK2A2 and telomere length. In fact, no variants of the CSNK2A2 locus were associated with cardiovascular disease (CHD) in Sikhs. In addition, CSNK2A2 may not have a direct role in the pathophysiology of telomeres.
The CSNK2A2 gene is found in South Asians only. It could not be detected in whites. Moreover, this gene phosphorylates another protein, telomeric repeat binding factor 1, which plays a key role in telomere length homoeostasis. These findings are promising, but further research is needed. The CSNK2A2 gene is involved in many different aspects of human health and we will need more information to fully understand its role in human disease.
There are several studies that support the association between this gene and T2D. However, the data have not been published yet. For this reason, we can't rely on the association between this gene and T2D. Nonetheless, the CSNK2A2 gene is an excellent candidate gene to study. Its association with T2D has been shown to be mediated by chromosome 5.
The CSNK2A2 marker is a monoclonal antibody raised against the full length recombinant form of CSNK2A2. The antibodies are suitable for immunofluorescence and ELISA. The optimal dilution will depend on the researcher. The antibodies recognize the CSNK2A2 protein in the cellular matrix. The antibodies are available in both human and murine forms.
CK2 is a serine/threonine protein kinase that is widely expressed. Its three catalytic subunits are encoded by two genes, the CSNK2A1 and CSNK2A2, and have approximately 90% homology between them within their catalytic domains. They are also conserved between species and are highly similar in their amino acid sequence. The two catalytic subunits of CK2 form a tetrameric holoenzyme, and the regulatory b subunit is unstable. When the protein is in an unstable state, it can dissociate from the holoenzyme.
The CSNK2A2 gene encodes a kinase that is normally tetrameric in structure. There are two catalytic subunits, the CSNK2A1 and CSNK2A2, and one regulatory subunit, CSNK2B. The catalytic subunits share ninety percent identity within the catalytic domains. The two catalytic subunits form a heterodimer, and the regulatory b subunit is unstable. Nevertheless, under physiological conditions, this dimer dissociates from the tetrameric holoenzyme.
Further, studies have shown that the CSNK2A2 SNP is associated with telomere length in some populations. Interestingly, this association was observed only in South Asians and was not replicated in white populations. Furthermore, CSNK2A2 has a known association with telomere attrition, age-dependent chronic disorders, and cardiometabolic risk in type 2 diabetes.
PMID: 2174700 by Lozeman F.J., et al. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.
PMID: 11239457 by Keller D.M., et al. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.