Cubilin (CUBN)

Cotransporter which plays a role in lipoprotein, iron and vitamin metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex.

The binding of all ligands requires calcium. Serves as significant transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac.