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- Table of Contents
Cubilin Antibodies
AND CUBN ELISA kits, Cubilin Proteins
Many biological assays use antibodies to detect Cubilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cubilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cubilin antibodies...
Designing an IHC experiment for Cubilin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CUBN IHC GuideCUBN Infographic by Boster Bio
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CUBN Overview
Facts about Cubilin.
Cubilin (CUBN)
Cotransporter which plays a role in lipoprotein, iron and vitamin metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex.
The binding of all ligands requires calcium. Serves as significant transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac.
Gene Information
| Human | |
|---|---|
| Gene Name: | CUBN |
| Uniprot: | O60494 |
| Entrez: | 8029 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
cubilin; cubilin (intrinsic factor-cobalamin receptor); Cubilin; CUBN; Cubulin; gp280; IFCR; MGA1
Molecular Weight
Mass (kDA):
398.736 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p13 |
| Sequence: | 10; NC_000010.11 (16823966..17130492, complement) |
Tissue Specificity
Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Subcellular Localizations
Apical cell membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, coated pit. Endosome. Lysosome membrane; Peripheral membrane protein. Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (PubMed:29402915, PubMed:30523278). Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity).
Diseases
- Anemia
- Malabsorption Syndrome
- Proteinuria Of Undiagnosed Cause
- Anemia, Megaloblastic
- Vitamin B 12 Deficiency
- Kidney Diseases
- Dysequilibrium Syndrome
- Congenital Abnormality
- Megaloblastic Anemia Due To Inborn Errors Of Metabolism
- Malignant Neoplasms
- Chronic Kidney Disease
- 5,10-methylenetetrahydrofolate Reductase Deficiency
Pathways
- Transport
- Excretion
- Gastrulation
- Endocytosis
- Pathogenesis
- Localization
- Glomerular Filtration
PTMs
- Cleavage on pair of basic residues
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CUBN
bosterbio.com/bosterbio-gene-info-cards/CUBN
References
PMID: 9572993 by Kozyraki R., et al. The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region.
PMID: 10371504 by Kozyraki R., et al. The intrinsic factor-vitamin B12 receptor, cubilin, is a high- affinity apolipoprotein A-I receptor facilitating endocytosis of high- density lipoprotein.