This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
DNAJB2 Antibodies
AND DNAJB2 ELISA kits, DNAJB2 Proteins
Many biological assays use antibodies to detect DNAJB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNAJB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNAJB2 antibodies...
Previous: CBLIF
Next: HSPA1L
DNAJB2 Infographic by Boster Bio
All DNAJB2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M08139
100 µl
Cat # M08139
100 µl
DNAJB2 Overview
Facts about DnaJ homolog subfamily B member 2.
DnaJ homolog subfamily B member 2 (DNAJB2)
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also results in the ubiquitin- dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540).
Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically be the ER-associated protein degradation of misfolded proteins (PubMed:15936278).
Gene Information
| Human | |
|---|---|
| Gene Name: | DNAJB2 |
| Uniprot: | P25686 |
| Entrez: | 3300 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DnaJ (Hsp40) homolog, subfamily B, member 2; HSJ-1; HSPF3neuronal DNAJ-like 1
Molecular Weight
Mass (kDA):
35.58 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (219279366..219286895) |
Tissue Specificity
More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272).
Subcellular Localizations
[Isoform 2]: Cytoplasm. Nucleus.; [Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.
Diseases
- Neurodegenerative Disorders
- Huntington Disease
- Atrophy
- Inflammation
- Weakness
- Infectious Mononucleosis
- Communicable Diseases
- Mitochondrial Diseases
- Muscular Dystrophy, Duchenne
- Parkinson Disease
- Myopathy
- Motor Neuron Disease
Pathways
- Protein Folding
- Neuroprotection
- Secretory Pathway
- Cytokine Production
- Cell Cycle
- Endocytosis
- Prenylation
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNAJB2
bosterbio.com/bosterbio-gene-info-cards/DNAJB2
References
PMID: 1599432 by Cheetham M.E., et al. Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons.
PMID: 7957263 by Cheetham M.E., et al. Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b.