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DOCK3 Antibodies
AND DOCK3 ELISA kits, DOCK3 Proteins
Many biological assays use antibodies to detect DOCK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOCK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOCK3 antibodies...
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DOCK3 Infographic by Boster Bio
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DOCK3 Overview
Facts about Dedicator of cytokinesis protein 3.
Dedicator of cytokinesis protein 3 (DOCK3)
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it could be involved in Alzheimer disease. Ectopic expression in neural cells reduces the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it might affect the role of a small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | DOCK3 |
| Uniprot: | Q8IZD9 |
| Entrez: | 1795 |
Family
| Belongs to: |
|---|
| DOCK family |
Alternative Names
dedicator of cytokinesis 3; DOCK3; KIAA0299; MOCA; modifier of cell adhesion
Molecular Weight
Mass (kDA):
233.103 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.2 |
| Sequence: | 3; NC_000003.12 (50674927..51384198) |
Tissue Specificity
In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
Subcellular Localizations
Cytoplasm.
Diseases
- Neoplasms
- Tissue Adhesions
- Neoplasm Metastasis
- Melanoma
- Malignant Neoplasms
- Alzheimer's Disease
- Cell Invasion
- Malnutrition
- Neurodegenerative Disorders
- Neoplasm Invasiveness
- Nervousness
- Attention Deficit Hyperactivity Disorder
Interacting Proteins
- NCK1
Pathways
- Cell Adhesion
- Proteolysis
- Cytokinesis
- Regeneration
- Cell-cell Adhesion
- Transport
- Cell Migration
- Establishment Of Cell Polarity
- Localization
- Cell Division
- Chemotaxis
PTMs
- Phosphorylation
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOCK3
bosterbio.com/bosterbio-gene-info-cards/DOCK3
References
PMID: 10854253 by Kashiwa A., et al. Isolation and characterization of novel presenilin binding protein.
PMID: 14569117 by De Silva M.G., et al. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.