Dedicator of cytokinesis protein 3 (DOCK3)

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.

Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it could be involved in Alzheimer disease. Ectopic expression in neural cells reduces the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it might affect the role of a small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).