- Table of Content
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is imperative to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important to get a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445).
|WD repeat cdt2 family|
|Sequence:||1; NC_000001.11 (212035553..212105013)|
Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.