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Facts about Denticleless protein homolog.
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is imperative to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important to get a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445).
Human | |
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Gene Name: | DTL |
Uniprot: | Q9NZJ0 |
Entrez: | 51514 |
Belongs to: |
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WD repeat cdt2 family |
CDT2RA-regulated nuclear matrix-associated protein; CDW1; DCAF2DDB1 and CUL4 associated factor 2; DDB1- and CUL4-associated factor 2; denticleless homolog (Drosophila); L2DTLRA regulated nuclear matrix associated protein; Lethal(2) denticleless protein homolog; RAMPdenticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein
Mass (kDA):
79.468 kDA
Human | |
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Location: | 1q32.3 |
Sequence: | 1; NC_000001.11 (212035553..212105013) |
Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
The DTL marker can be used to optimize your experiments. This is the right place for you. You may have heard of the Boster Bio. But, did you know about the DTL Marker. The DTL Marker has many benefits. You'll learn why the DTL Marker is so useful in your experiments after you read his bio. The optimization tool can also be used to determine the best flow process for your experiments.
The Biographers International Organization and the New York University's Biography Seminar have outlined the best uses for the DTL Marker. These guidelines were created and edited by Kai Bird, legal scholars, and several New York publishing attorneys. Biographers should consider these guidelines when writing their biography. Fair use allows authors the freedom to use older works in order to create new ones.
The best biography bios will start with the writer’s birth, childhood, as well as their life experiences. This includes the place and time of birth as well their childhood environment. The biography should then cover their adult lives, including key turning points or important life events. The bio should also include the person's legacy. This will allow readers to learn more about the person.
Fair use is an important legal standard in biographies. This standard requires that biographers recreate the subject's world in order to explain their role within it. The DTL Marker is a tool that writers can use to avoid copyright problems and other legal issues. It also ensures that they have fair use policies. Many writers rely this standard to ensure that they are not misused.
The DTL Marker, a powerful tool for illustrating a biographie, is excellent. It's easy-to-use and works in any environment, whether it's a museum or a book club. It can be used for personal projects. You can create a biography for yourself or someone else. This is an excellent tool to remember and use. The DTL Marker has many uses.
1993 saw the debut of the first Boster Bio product. This product quickly earned the nickname "he that converts science in a lavatory". In the years that followed, Steven Boster produced several products for IHC, and also developed hundreds of primary antibodies. Boster Bio soon became China's largest anti-virus catalog company. Steven Boster was the inventor of the PicoKine(tm), a patent platform that he adapted to create a high-sensitivity ELISA test kit.
PMID: 11278750 by Cheung W.M., et al. Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation.
PMID: 16861906 by Higa L.A., et al. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.