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Facts about Enhancer of mRNA-decapping protein 4.
Promotes complex formation between DCP1A and DCP2. Enhances the catalytic action of DCP2 (in vitro).
Human | |
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Gene Name: | EDC4 |
Uniprot: | Q6P2E9 |
Entrez: | 23644 |
Belongs to: |
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WD repeat EDC4 family |
Autoantigen Ge-1; Autoantigen RCD-8; enhancer of mRNA decapping 4; enhancer of mRNA-decapping protein 4; Ge-1; Hedls; HEDLSHuman enhancer of decapping large subunit; RCD-8
Mass (kDA):
151.661 kDA
Human | |
---|---|
Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (67873052..67884499) |
Cytoplasm, P-body. Nucleus.
Boster offers high-affinity prima antibodies to help you choose the right antibodies for your research. These antibodies have been validated for Western Blotting, Immunohistochemistry, and ELISA. They are highly effective and have been well cited in research journals for over 25 years. This means they are highly reliable and trusted by researchers. This article will provide more information.
High-affinity primary antibodies can detect target antigens with high specificity and affinity. Primary antibodies are immunoglobulins. The assay requirement will determine how they should be conjugated. Conjugated antibodies eliminate secondary antibodies. High-affinity prima antibodies can detect many targets and can be used for immunoblotting.
To perform HA pulldowns we first lysed parental HeLa cell with 1 mg/ml FLAG tagged TNF-a. After that, the cells were lysed by 1 ml RIPA Buffer containing 50mMTris-HCl pH 7.5, 1% NaN, 0.5% sodium dioxycholate, protease inhibitors, and M1-TUBE biotin. The samples were then washed with reaction buffer without BSA three more times.
EDCs are useful for brain research and neurogenesis. Hamad, et al. discovered that EDC4 had a negative effect on the visual system, and decreased neurogenesis. More research is needed to confirm that EDC4 is a factor in neurogenesis. Bosterbio products are able to conduct sensitive colorimetric analysis to identify viable cells.
ERdj3Fc is a purified version of ERdj3. Purified ERdj3Fc has been applied to P19 cells transfected using Ascl1, reducing TuJ1+ neurons. The effect was reversed when PRTGFc is used and a -PRTG1 MAb is used. This suggests that they may collaborate to control neurogenesis.
Scientists are learning more about BDNF's role in plasticity. It has been demonstrated in petri dishes that BDNF can help brain cells grow new branches. This is an important activity for establishing new cell connections. It regulates glucose metabolism to prevent exhaustion of the b cells. But what are its greatest uses? Let's find it!
BDNF belongs to the neurotrophin family and plays an important role during neural development. It is found in both the axons and dendrites of neurons. BDNF expression is found throughout the peripheral nerve system. BDNF is expressed throughout the body. This allows it to have a wide range of beneficial effects. It is a neurotrophin. This means it regulates excitatory, inhibitory synaptic transmission, and activity-dependent plasticity.
Brain-derived Neurotrophic Factor is a molecule located in the brain that is associated to many neurologic conditions. It is involved in memory and plasticity changes related learning. Hyperglycemia can reduce BDNF's output to the peripheral circulation, which can affect cognitive performance. There are many interventions that can boost BDNF production.
BDNF may be important in the etiology for Alzheimer's. Although BDNF levels are significantly lower among AD patients than in the controls, TrkB levels are not affected. BDNF is also associated with improved cognitive function and reduced synaptic dysfunction. It is possible that BDNF could also be involved in neuronal degeneration due to lesion-induced damage.
PMID: 7520377 by Bloch D.B., et al. The immunoreactive region in a novel autoantigen contains a nuclear localization sequence.
PMID: 9067524 by Garcia-Lozano J.R., et al. Cytoplasmic detection of a novel protein containing a nuclear localization sequence by human autoantibodies.