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- Table of Contents
Facts about EH domain-containing protein 3.
Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport.
| Human | |
|---|---|
| Gene Name: | EHD3 |
| Uniprot: | Q9NZN3 |
| Entrez: | 30845 |

| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |

EH domain containing 3; EH domain-containing protein 3; EHD2; EH-domain containing 3; PAST homolog 3; PAST3
Mass (kDA):
60.887 kDA

| Human | |
|---|---|
| Location: | 2p23.1 |
| Sequence: | 2; NC_000002.12 (31234152..31269451) |
Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.
Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (By similarity). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:20489164). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippoc





PMID: 10673336 by Pohl U., et al. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.
PMID: 12121420 by Galperin E., et al. EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.