- Table of Content
Especially required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also has an early role before its assembly into from the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site.
|Sequence:||19; NC_000019.10 (18442663..18522070, complement)|
Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
Nucleus. Nucleus speckle. Nucleus, Cajal body. Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes(PubMed:23932780).