FGD1 Antibodies

AND FGD1 ELISA kits, FGD1 Proteins

Many biological assays use antibodies to detect FGD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGD1 antibodies...

We validate the specificity of these antibodies to FGD1 by testing them on tissues known to express FGD1 positively and negatively. Browse below to find the FGD1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FGD1 Infographic by Boster Bio

All FGD1 Products

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Product

Figures

Specificity

Applications

Price

FGD1 (NM_004463) Human Recombinant Protein

Coomassie blue staining of purified FGD1 protein

$1249
Cat # PROTP98174
20 µg

FGD1 (NM_004463) Human Over-expression Lysate

Human

$628
Cat # LS002245
20 µg, 100 µg

Anti-FGD1 Antibody

Human, Mouse, Rat

ELISA, IP, IF, IHC, ICC, WB

$370
Cat # A05036-1
100 μl/vial

FGD1 Overview

Facts about FYVE, RhoGEF and PH domain-containing protein 1.

FGD1 3D structure. Source: alphafold

FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP.
Plays a role in regulating the actin cytoskeleton and cell shape.

Gene Information

Human
Gene Name:	FGD1
Uniprot:	P98174
Entrez:	2245

Family

Belongs to:

No superfamily

Alternative Names

faciogenital dysplasia (Aarskog-ScRhoGEF and PH domain-containing protein 1; Faciogenital dysplasia 1 protein; FGDYMRXS16; FYVE, RhoGEF and PH domain containing 1; Rho/Rac guanine nucleotide exchange factor FGD1; ZFYVE3AAS; Zinc finger FYVE domain-containing protein 3

Molecular Weight

Mass (kDA):
106.561 kDA

Genomic Context


Human

Location:	Xp11.22
Sequence:	X; NC_000023.11 (54445454..54496234, complement)

Tissue Specificity

Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.

Subcellular Localizations

Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.

Diseases

Dysplasia
Dwarfism
Urogenital Abnormalities
Genetic Diseases, X-linked
Developmental Disabilities
Congenital Heart Defects
Congenital Hand Deformities
Craniofacial Abnormalities
Cell Transformation, Neoplastic
Tuberculosis
Neoplasms

Orbital Separation Excessive
Brachydactyly
Tissue Adhesions
Malnutrition
Hypoplasia

Pathways

Cell Motility
Localization
Cell Growth
Transport
Cell Migration
Cell Division
Translation
Cell Cycle
Bone Development
Pathogenesis
Transposition
Osteoblast Differentiation
Brain Development

Ossification
Podosome Assembly
Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
System Development
Cell Morphogenesis
Central Nervous System Development

PTMs

Phosphorylation

Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGD1

References

PMID: 7954831 by Pasteris N.G., et al. Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor.

PMID: 8969170 by Zheng Y., et al. The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs- specific guanine-nucleotide exchange factor.