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Phospholemman Antibodies
AND FXYD1 ELISA kits, Phospholemman Proteins
Many biological assays use antibodies to detect Phospholemman, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Phospholemman in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Phospholemman antibodies...
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FXYD1 Overview
Facts about Phospholemman.
Phospholemman (FXYD1)
Associates with and Modulates the activity of This sodium/potassium-transporting ATPase (NKA) which transports Na(+) from the cell and K(+) into the cell.
Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated.Reduce glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons that secrete gonadotropin-releasing hormone.
Gene Information
| Human | |
|---|---|
| Gene Name: | FXYD1 |
| Uniprot: | O00168 |
| Entrez: | 5348 |
Family
| Belongs to: |
|---|
| FXYD family |
Alternative Names
FXYD domain containing ion transport regulator 1; FXYD domain-containing ion transport regulator 1; MGC44983; PLMphospholemman
Molecular Weight
Mass (kDA):
10.441 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.12 |
| Sequence: | 19; NC_000019.10 (35137206..35143109) |
Tissue Specificity
Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.
Subcellular Localizations
Cell membrane, sarcolemma; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Membrane, caveola. Cell membrane, sarcolemma, T-tubule. Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks.
Diseases
- Rett Syndrome
- Hypertrophy
- Myocardial Ischemia
- Cardiac Hypertrophy
- Lung Diseases
- Lung Diseases, Obstructive
- Malignant Neoplasms
- Neoplasms
- Heart Failure
- Macule
- Chronic Obstructive Airway Disease
- Cardiovascular Diseases
Pathways
- Transport
- Dna Methylation
- Ion Homeostasis
- Methylation
- Ion Transport
- Muscle Contraction
- Protein Transport
- Cellular Ion Homeostasis
- Chemotaxis
- Coagulation
- Hemostasis
- Tubuloglomerular Feedback
- Lymphocyte Activation
PTMs
- Phosphorylation
- Methylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FXYD1
bosterbio.com/bosterbio-gene-info-cards/FXYD1
References
PMID: 9169143 by Chen L.-S.K., et al. Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1.
PMID: 10950925 by Sweadner K.J., et al. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.