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- Table of Contents
Facts about Frizzled-10.
Receptor for Wnt proteins.
Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.
Human | |
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Gene Name: | FZD10 |
Uniprot: | Q9ULW2 |
Entrez: | 11211 |
Belongs to: |
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G-protein coupled receptor Fz/Smo family |
CD350 antigen; CD350; frizzled (Drosophila) homolog 10; frizzled homolog 10 (Drosophila); Frizzled10; Frizzled-10; Fz10; FZ-10; FZD10; FzE7; hFz10
Mass (kDA):
65.336 kDA
Human | |
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Location: | 12q24.33 |
Sequence: | 12; NC_000012.12 (130162459..130165740) |
Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Cell membrane; Multi-pass membrane protein.
PMID: 10448064 by Koike J., et al. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family.
PMID: 9707618 by Tanaka S., et al. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.
*More publications can be found for each product on its corresponding product page