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- Table of Contents
Frizzled-10 Antibodies
AND FZD10 ELISA kits, Frizzled-10 Proteins
Many biological assays use antibodies to detect Frizzled-10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Frizzled-10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Frizzled-10 antibodies...
Designing a Western blot for Frizzled-10? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FZD10 Western Blot GuideFZD10 Infographic by Boster Bio
All FZD10 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07549
100 μg
Cat # M07549
100 μg
FZD10 Overview
Facts about Frizzled-10.
Frizzled-10 (FZD10)
Receptor for Wnt proteins.
Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.
Gene Information
| Human | |
|---|---|
| Gene Name: | FZD10 |
| Uniprot: | Q9ULW2 |
| Entrez: | 11211 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor Fz/Smo family |
Alternative Names
CD350 antigen; CD350; frizzled (Drosophila) homolog 10; frizzled homolog 10 (Drosophila); Frizzled10; Frizzled-10; Fz10; FZ-10; FZD10; FzE7; hFz10
Molecular Weight
Mass (kDA):
65.336 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.33 |
| Sequence: | 12; NC_000012.12 (130162459..130165740) |
Tissue Specificity
Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Carcinogenesis
- Malignant Neoplasm Of Stomach
- Sarcoma
- Synovial Sarcoma
- Stomach Neoplasms
- Embryonal Carcinoma
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
- Malignant Tumor Of Cervix
- Hemorrhage
Interacting Proteins
- HILPDA
Pathways
- Cell Growth
- Cell Fate Determination
- Rna Interference
- Cell Proliferation
- Gland Development
- Cell Adhesion
- Clathrin-mediated Endocytosis
- Cell Migration
- Aging
- Lung Development
- Immune Response
- Mesoderm Formation
- Limb Development
PTMs
- Phosphorylation
Research Areas
- GPCR
- Growth and Development
- Neuronal Cell Markers
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FZD10
bosterbio.com/bosterbio-gene-info-cards/FZD10
References
PMID: 10448064 by Koike J., et al. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family.
PMID: 9707618 by Tanaka S., et al. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.
1 Publications of Boster Frizzled-10 Antibodies & ELISA Kits
- PubMed ID: 27987338, Rong-Feng Wu, Hui-Ming Yang, Wei-Dong Zhou, Li-Rong Zhang, Jian-Bing Bai, Dian-C...
*More publications can be found for each product on its corresponding product page